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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 941-396-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles. As the substance is a breakdown product of the target substance, this study is considered valid for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Study of Intra- and Interlaboratory Variability in the Results of Rabbit Eye and Skin Irritation Tests
- Author:
- Weil, C.S. and Scala, R.A.
- Year:
- 1 971
- Bibliographic source:
- Toxicol. Appl. Pharmacol., 19, 276-360
- Reference Type:
- secondary source
- Title:
- OECD SIDS Initial Assessment Report For SIAM 14 - Glycerol
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- http://www.inchem.org/documents/sids/sids/56815.pdf
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Limited reporting
- Principles of method if other than guideline:
- During a study on interlaboratory testing program, glycerol was used together with various other substances. A reference method comparable to OECD 405 and non-reference methods have been used by the different laboratories.
- GLP compliance:
- no
Test material
- Reference substance name:
- Glycerol
- EC Number:
- 200-289-5
- EC Name:
- Glycerol
- Cas Number:
- 56-81-5
- IUPAC Name:
- glycerol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: Male
- Age at study initiation:
- Weight at study initiation: At least 2 kg
- Housing: The animals were housed singly and free of any extraneous material which might cause irritation.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes, other substances used
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- Single application without washing
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM:
The grading of eye irritation was according to the scale of Draize et al. (1944). Injuries such as pannus, keratoconus, and sloughing of corneal epithelium were not included in the Draize system and were recorded separately.
Observations on any animal were discontinued after 24 or 72 hr if the eyes were free of irritation.
TOOL USED TO ASSESS SCORE: Fluorescein (Fluorescein staining was done at 24 and 72 hr and 7 days on the eyes of animals not previously negative)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- < 2
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Glycerol was found to be non-irritating to eyes In 19 laboratories, while in one laboratory it results in questionable irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test results of the different laboartory participating the study show that Glycerol can be regarded as not irritating to eyes.
- Executive summary:
Glycerol was not found to be irritating to eyes in survey evaluating intra- and interlaboratory variabilities in testing on skin and eye irritation. Beside laboratory-specific methods, a reference method comparable to OECD 405 has been used by the laboratories using the Draize scoring system to compare the results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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