Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-003-3 | CAS number: 91031-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Studies investigating the terrestrial toxicity of Fatty acids, C8 -10, octyl esters (CAS 91031-90-0) are not available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, read-across to the structurally similar substances isopropyl myristate (CAS 110-27-0) and Fatty acids, C16-18 and C18-unsaturated, 2-ethylhexyl esters (CAS 85049-37-2) was conducted.
The target and source substance are monoesters of primary and secondary alcohols and linear C8 –C17 fatty acids. The target substance fatty acids, C8 -10, octyl esters is an UVCB substance comprising linear C8-10 fatty acids esterified with octanol. The two source substances isopropyl myristate (CAS 110-27-0) and Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2) are linear saturated and unsatured fatty acids with a chain length of C14 - C18. The fatty acid chains are esterified with a primary alcohol. The target and source substances are characterised by similar physico-chemical properties. All substances are readily biodegradable, poorly soluble in water (WS <0.05 mg/L) and are not volatile (VP <0.1 Pa). The log Kow of target and source substances is generally high (>6.5) and increases with fatty acid chain length. The similarities in the physico-chemical properties indicate that soil is the main target compartment for target and and source substances. The available results on the aquatic toxicity of the source substances are furthermore indicative for a similar toxicilogial profile. For a detailed review of the data matrix please refer to the analogue justification attached in section 13 in IUCLID.
Due to their low solubility and high adsorption potential, Fatty acids, C8-10, octyl esters isexpected to mostly sorb to soil natural organic matter, in terrestrial systems. Concentrations in soil pore water are expected to be low, also due to ready biodegradation. The substance will therefore be relevant for uptake mainly for soil dwelling organisms feeding on soil organic matter, such as earthworms.
The assessment of the toxicity to terrestrial macroorganisms is based on data available for the source substance isopropyl myristate (CAS 110-27-0). The toxicity of isopropyl myristate to Eisenia fetida was tested in a study following OECD 207. No mortality was observed during the 14-day exposure period at the test concentration of 20,000 mg/kg. Additionally, data is also available for the toxicity of the source substance Fatty acids, C16-18 and C18-unsaturated, 2-ethylhexyl esters (CAS 85049-37-2) to terrestrial plants. The 21-day NOEC value is determined to be 100 mg/kg for all plants tested, and EC50 values between 390 and 600 mg/kg are reported.
Based on the available data, the terrestrial toxicity of the source substances is indicated to be very low. Since both the source substances and the target substance are poorly soluble in water, have high adsorption potential and a high log Kow, their behaviour in the terrestrial compartment is expected to be similar. The available earthworm study can therefore be used as part of a read-across approach for Fatty acids, C8-10, octyl esters.
Furthermore, Fatty acids, C8-10, octyl estersis expected to be metabolised by organisms after ingestion, which is considered to be the main uptake route. Esters of primary alcohols, containing from 1 to 18 carbon atoms, with fatty acids, containing from 2 to 18 carbon atoms, have shown to be hydrolysed by pancreatic lipases in a study by Mattson and Volpenhein (Mattson and Volpenhein 1972). Measured rates of enzyme catalysed hydrolysis varied between 2 and 5 µeq/min/mg enzyme for the different chain lengths. The resulting free fatty acids and alcohols are absorbed from the intestine into the blood stream. The alcohols are metabolised primarily in the liver through a series of oxidative steps, finally yielding carbon dioxide (Berg et al. 2002). Fatty acids are either metabolised via the beta-oxidation pathway in order to generate energy for the cell or reconstituted into glyceride esters and stored in the fat depots in the body (Berg et al. 2002).
Based on the available information, toxicity of Fatty acids, C8-10, octyl esters (CAS 91031-98-0) to terrestrial organisms is not expected to be of concern, and consequently, no further testing is proposed.
References:
Berg JM, Tymoczko JL, Stryer L. 2002. Biochemistry, 5thedition, W.H. Freeman and Company
Mattson FH, Volpenhein RA. 1969. Relative rates of hydrolysis by rat pancreatic lipase of esters of C2-C18 fatty acids with C1-C18 primary n-alcohols, J Lipid Res 10: 271-276
Tocher DR. 2003. Metabolism and functions of lipids and fatty acids in teleost fish.Rev Fisheries Sci 11(2): 107-184
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.