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EC number: 219-058-5 | CAS number: 2344-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Chloromethyltrimethylsilane
- EC Number:
- 219-058-5
- EC Name:
- Chloromethyltrimethylsilane
- Cas Number:
- 2344-80-1
- Molecular formula:
- C4H11ClSi
- IUPAC Name:
- (chloromethyl)trimethylsilane
- Reference substance name:
- Silane,(chloromethyl)trimethyl-
- IUPAC Name:
- Silane,(chloromethyl)trimethyl-
- Test material form:
- other: colourless liquid
- Details on test material:
- Purity 99.8%
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- New Zealand White Rabbits Hsdlf:NZW.
Source: Harlan Winkelmann GmbH, D-33178 Borchen
3 female animals were used.
The animals were derived from a controlled full barrier maintained breeding
system (SPF).
Semi-barrier in an air conditioned room
Temperature: 18 ±3 QC
ReI. humidity: 55 ± 10%
Artificial light, sequence being 12 hours light, 12 hours dark
Air change: at least 10 x / hour
Free access to ssniff K-H, 4 mm V2333-000 complete diet for rabbits maintenance,
rich in crude fibre, totally pathogene free (TPF)
Free access to tap water (drinking water, municipal residue control,
microbiol. controlled periodically)
Certificates of food, water and bedding are filed at BSL Bioservice
Housed in ABS - plastic rabbit cages, floor 4200 cm2
Adequate acclimatization period
Approximately 24 hours before the test, fur was removed. from the dorsal
area of the trunk by clipping.
The test item was applied as a single dose to a small area (approx. 6 cm2
) of
skin on one side of the dorsal area and covered with a gauze patch, which
was held in place with non-irritating tape. The untreated other side served as
control. The test item was applied to a patch first, and then applied to the
skin. The patch was fixed with a semi-occlusive dressing.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin served as control.
- Amount / concentration applied:
- A dose of 0.5 mL ofthe test item was applied to each test site.
- Duration of treatment / exposure:
- Test item was held in contact with the skin throughout a 4-hour period. At
the end of the exposure period residual test item was removed from the first
animal by using tap water. - Observation period:
- Animals were examined for signs of erythema and oedema at 1, 24, 48 and
72 hours after patch removal. For animal No. 2 the observation period was
extended until 7 days after patch removal, when all symptoms had
disappeared. - Number of animals:
- 3 female animals
- Details on study design:
- For the determination of classification-relevant values, the animals were
examined for signs of erythema and oedema at 24, 48 and 72 hours after
patch removal.
Individual reactions of each animal were recorded at each observation time.
Nature, severity and duration of all lesions observed were described.
Body weights were recorded at the start and at the end of the study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0.89
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0
- Irritant / corrosive response data:
- Reversibility of any observed effect:
Animal No. 1: No treatment related effects observed.
Animal No. 2: Changes fully reversible within 7 days after patch removal.
Animal No. 3: Changes fully reversible within 72 hours after patch removal.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Considering the reported data of this irritation study it can be stated that the
test item Chloromethyltrimethylsilane showed slight irritant, but no
corrosive effects.
According to the EC criteria for classification and labelling requirements for
dangerous substances and preparations (Guidelines in Commission Directive
93/21 EEC) and GHS criteria (First Revised Edition, 2005) the test item
Chloromethyltrimethylsilane does not have to be classified and has no
obligatory labelling requirement for skin irritation. - Executive summary:
Number of animals: 3
Duration of exposure: 4 hours
Amount of substance: 0.5 mL per test site
Type of dressing: semi-occlusive
Vehicle (moistening): no vehicle used
Reversibility of any observed effect:
Animal No. 1: No treatment related effects observed.
Animal No. 2: Changes fully reversible within 7 days after patch removal.
Animal No. 3: Changes fully reversible within 72 hours after patch removal.
Considering the reported data of this irritation study it can be stated that the
test item Chloromethyltrimethylsilane showed slight irritant, but no
corrosive effects.
According to the EC criteria for classification and labelling requirements for
dangerous substances and preparations (Guidelines in Commission Directive
93/21 EEC) and GHS criteria (First Revised Edition, 2005) the test item
Chloromethyltrimethylsilane does not have to be classified and has no
obligatory labelling requirement for skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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