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EC number: 285-203-4 | CAS number: 85049-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Apr - 19 Mai 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- GLP-Guideline study with acceptable restrictions (no information on type of filter).
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control - stock solution - 2.7 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Application of 1 g/L in synthetic freshwater and stirred for 18 h. This solution was filtered and the DOC was analysed in the filtrate. The test substance concentration (2.7 mg/L nominal) was calculated on the basis of DOC measurement of stock solution.
- Eluate: No
- Differential loading: No
- Controls: yes, water control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Clone 5
- Source: own breeding
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: Daphnids were held in M4-medium in 1 L glass-beakers and fed with Scenedesmus subspicatus every day. The water was changed every second or third day and the offspring was removed. Every 4 weeks the offspring was used for further breeding. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 8.2 - 8.5 mg/L
- Nominal and measured concentrations:
- nominal: control - 2.7 mg/L
measured:
control: 0 mg/L (0 h), 0.19 mg/L (48 h)
stock solution: 3.0 mg/L (0 h)
2.7 mg/L test concentration: 2.5 mg/L (0 h), 2.3 mg/L (48 h) - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, fill volume: glass vessels, fill volume: 10 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic freshwater was used for the preparation of mineral medium. Synthetic freshwater contained 294 mg/L CaCl2 x 2 H2O, 123 mg/L MgSO4 x 7 H2O, 63 mg/L NaHCO3, 5.5 mg/L KCl.
OTHER TEST CONDITIONS
- Photoperiod: complete darkness
EFFECT PARAMETERS MEASURED: Immobilisation was recorded after 24 and 48 h.
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: The test concentration of 2.7 mg/L is the highest soluble concentration. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 2.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: 35% (1.0 mg/L), 100% (2.0 mg/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- After 48 hours the EL50 was determined to be > 2.4 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- GLP Guideline study with acceptable restrictions (Calculation of test concentration; No information on filter)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Prior testing, the stock solution was sampled/measured once.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 1 g/L was dissolved in water, stirred for 18 h and filtered.
- Eluate: no
- Differential loading: no
- Controls: yes, water control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: clone 5
- Source: In-house culture
- Age at study initiation: < 24 h
- Method of breeding: Daphnia were held in Elendt M4-medium in 1 L beakers. They were fed daily with Scenedesmus subspicatus. The water was changed every second or third day and the offspring was removed. After approx. 4 weeks the young daphnids were isolated and used for breeding.
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.9 - 8.0
- Dissolved oxygen:
- 7.7 - 8.1 mg/L
- Nominal and measured concentrations:
- nominal: 0, 1000 mg/L
measured: 2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: test tubes
- Material, fill volume: glass, Fill volume: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
- Biomass loading rate: approx. 2 mL/test organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline 92/69/EWG C.2
- Culture medium different from test medium: yes, Elendt M4 medium was used for breeding and synthetic freshwater was used for testing.
OTHER TEST CONDITIONS
- Photoperiod: complete darkness
EFFECT PARAMETERS MEASURED: Immobilisation was recorded every 24 h. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Immobilisation: 40% (1 mg/L), 100% (2 mg/L)
- Validity criteria fulfilled:
- yes
- Conclusions:
- After 48 hours, the EL50 was determined to be > 2 mg/L and the NOEC was determined to be 2 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- GLP Guideline study with acceptable restrictions (Calculation of test concentration; No information on filter)
- Justification for type of information:
- Please refer section 13 for read across justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Prior testing, the stock solution was sampled/measured once.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 1 g/L was dissolved in water, stirred for 18 h and filtered.
- Eluate: no
- Differential loading: no
- Controls: yes, water control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: clone 5
- Source: In-house culture
- Age at study initiation: < 24 h
- Method of breeding: Daphnia were held in Elendt M4-medium in 1 L beakers. They were fed daily with Scenedesmus subspicatus. The water was changed every second or third day and the offspring was removed. After approx. 4 weeks the young daphnids were isolated and used for breeding.
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.9 - 8.0
- Dissolved oxygen:
- 7.7 - 8.1 mg/L
- Nominal and measured concentrations:
- nominal: 0, 1000 mg/L
measured: 2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: test tubes
- Material, fill volume: glass, Fill volume: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
- Biomass loading rate: approx. 2 mL/test organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline 92/69/EWG C.2
- Culture medium different from test medium: yes, Elendt M4 medium was used for breeding and synthetic freshwater was used for testing.
OTHER TEST CONDITIONS
- Photoperiod: complete darkness
EFFECT PARAMETERS MEASURED: Immobilisation was recorded every 24 h. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Immobilisation: 40% (1 mg/L), 100% (2 mg/L)
- Validity criteria fulfilled:
- yes
- Conclusions:
- After 48 hours, the EL50 was determined to be > 2 mg/L and the NOEC was determined to be 2 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 11 Apr - 19 Mai 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- GLP-Guideline study with acceptable restrictions (no information on type of filter).
- Justification for type of information:
- Please refer section 13 for read acrss justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control - stock solution - 2.7 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Application of 1 g/L in synthetic freshwater and stirred for 18 h. This solution was filtered and the DOC was analysed in the filtrate. The test substance concentration (2.7 mg/L nominal) was calculated on the basis of DOC measurement of stock solution.
- Eluate: No
- Differential loading: No
- Controls: yes, water control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Clone 5
- Source: own breeding
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: Daphnids were held in M4-medium in 1 L glass-beakers and fed with Scenedesmus subspicatus every day. The water was changed every second or third day and the offspring was removed. Every 4 weeks the offspring was used for further breeding. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 8.2 - 8.5 mg/L
- Nominal and measured concentrations:
- nominal: control - 2.7 mg/L
measured:
control: 0 mg/L (0 h), 0.19 mg/L (48 h)
stock solution: 3.0 mg/L (0 h)
2.7 mg/L test concentration: 2.5 mg/L (0 h), 2.3 mg/L (48 h) - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, fill volume: glass vessels, fill volume: 10 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic freshwater was used for the preparation of mineral medium. Synthetic freshwater contained 294 mg/L CaCl2 x 2 H2O, 123 mg/L MgSO4 x 7 H2O, 63 mg/L NaHCO3, 5.5 mg/L KCl.
OTHER TEST CONDITIONS
- Photoperiod: complete darkness
EFFECT PARAMETERS MEASURED: Immobilisation was recorded after 24 and 48 h.
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: The test concentration of 2.7 mg/L is the highest soluble concentration. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 2.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- (WAF)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: 35% (1.0 mg/L), 100% (2.0 mg/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- After 48 hours the EL50 was determined to be > 2.4 mg/L.
Referenceopen allclose all
Table 1: Number of mobile and immobile daphnia after 24 and 48 h of exposure
Concentration [mg/L] |
24 h |
48 h |
||||
No. mobile |
No. immobile |
% immobile |
No. mobile |
No. immobile |
% immobile |
|
Control |
20 |
0 |
0 |
20 |
0 |
0 |
2.7 mg/L (nominal) |
20 |
0 |
0 |
20 |
0 |
0 |
Table 1: Number of mobile and immobile daphnia after 24 and 48 h of exposure
Concentration [mg/L] |
24 h |
48 h |
||||
No. mobile |
No. immobile |
% immobile |
No. mobile |
No. immobile |
% immobile |
|
Control |
20 |
0 |
0 |
20 |
0 |
0 |
2.7 mg/L (nominal) |
20 |
0 |
0 |
20 |
0 |
0 |
Description of key information
No toxic effects to aquatic invertebrates up to the limit of water solubility.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 2 mg/L
Additional information
Since no studies investigating the short-term toxicity to aquatic invertebrates of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across conducted to the two structurally related substances decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8). This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.
The study with decanoic acid, mixed diesters with octanoic acid and propylene glycol was performed according to the EU Method C.2 under GLP conditions (Scholz, 1995). Daphnia magna was exposed to a measured concentration (geometric mean) of 2.4 mg/L in a static limit test for 48 h. Since the test solution was prepared by adding 1 g/L with subsequent filtration (WAF), the measured concentration of 2.4 mg/L represents the highest concentration which is soluble in water. No effects were observed resulting in an EL50 of > 2.4 mg/L.
The second study using butylene glycol dicaprylate / dicaprate supports this result (Scholz, 1997). It was conducted under the same conditions like the first study. Daphnia magna was exposed to a measured concentration (initial) of 2 mg/L in a static limit test for 48 h. The test concentration of 2 mg/L represents the highest soluble concentration, since 1 g/L was added to the test medium, stirred and subsequently filtered (WAF). No effects were observed, resulting in an EL50 of > 2 mg/L.
Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit acute toxic effects to aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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