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Diss Factsheets
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EC number: 210-890-4 | CAS number: 625-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No approproate data available.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the available study examining a structural analogue of the test substance, classification for carcinogenicity is not possible in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Additional information
No studies on the carcinogenicity of 3 -chloropropionyl chloride were available. However, Article 13 of REACH states that, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. One carcinogenicity study is available for the structural analogue 3- Chloropropionic acid.
In a in vivo carcinogenicity study by Theiss (1979), the abilities of 28 organohalides (of which the test substance) to induce lung tumors in strain A mice were investigated. Groups of 20 mice (10 males and 10 females were given 3 times weekly i.p. injections for a maximum of eight weeks with 0.14, 0.28, and 0.56 mmol/kg test substance dissolved in 0.9% NaCl solution. Twenty-four weeks after the first injection, the mice were sacrificed. The frequency of lung tumors in each chemically treated group was statistically compared with that in the appropriate vehicle-treated control group. In the control group all animals survived and the average number of lung tumors per mouse was 0.10 ± 0.10. At 0.14 mmol/kg 19/20 animals survived and the average number of lung tumors per mouse was 0.32 ± 0.11. At 0.28 mmol/kg all animals survived and the average number of lung tumors per mouse was 0.20 ± 0.12. At the highest doese of 0.56 mmol/kg only 12 injections (instead of 24) were given due to toxicity concerns. Only 10/20 animals survived treatment and the average number of lung tumors per mouse was 0.90 ± 0.28, which was statistally significant compared to control. In this study there were only 3 doses tested of which the highest dose exceeded the maximum tolerated dose. I.p injection is not a relevant exposure route for this type of examination. In addition, only 20 animals per dose were tested (instead of at least 50) and only a 8 week exposure protocol was used and test was terminated 24 weeks after first injection. Therefore, the results from this particular study are not suitable for assessment of the carcinogenic potential of the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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