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Diss Factsheets
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EC number: 201-942-7 | CAS number: 89-81-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- The study was conducted in 1975.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Thirty one healthy inmate volunteers were screened and twenty seven completed the experiment.
The materials were pre-tested on all subjects in order to determine whether sodium lauryl sulphate pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No evidence of irritation was observed and all subjects were pre-tested with 5 % SLS.
The materials were applied under occlusion to the same site on the volar aspects of the forearm of all subjects for five alternate day 48 hours periods. Patch sites were pre-treated for 24 hours with 5 % aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of the test material was applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 2 % aqueous SLS under occlusion on the left side of the back whereas the test materials were applied without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labelled site 5. - GLP compliance:
- no
- Remarks:
- Pre-dates GLP.
- Type of study:
- other: Modified maximisation test
Test material
- Reference substance name:
- 6-isopropyl-3-methylcyclohex-2-enone
- EC Number:
- 201-942-7
- EC Name:
- 6-isopropyl-3-methylcyclohex-2-enone
- Cas Number:
- 89-81-6
- Molecular formula:
- C10H16O
- IUPAC Name:
- 6-isopropyl-3-methylcyclohex-2-enone
- Test material form:
- not specified
- Details on test material:
- Name: Piperitone
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- other: Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- No data
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- No data
- No. of animals per dose:
- Twenty seven completed the experiment.
- Details on study design:
- Thirty one healthy inmate volunteers were screened and twenty seven completed the experiment.
The materials were pre-tested on all subjects in order to determine whether sodium lauryl sulphate pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No evidence of irritation was observed and all subjects were pre-tested with 5 % SLS.
The materials were applied under occlusion to the same site on the volar aspects of the forearm of all subjects for five alternate day 48 hours periods. Patch sites were pre-treated for 24 hours with 5 % aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of the test material was applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 2 % aqueous SLS under occlusion on the left side of the back whereas the test materials were applied without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labelled site 5. - Positive control substance(s):
- not specified
Results and discussion
Any other information on results incl. tables
The test substance produced no significant reactions that were considered irritant or allergic in the twenty seven subjects tested.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance produced no significant reactions that were considered irritant or allergic in the twenty seven subjects tested.
- Executive summary:
The test substance was assessed for skin sensitisation potential on twenty seven human volunteers. The test substance produced no significant reactions that were considered irritant or allergic in the twenty seven subjects tested.
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