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EC number: 217-006-6 | CAS number: 1719-57-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Chloro(chloromethyl)dimethylsilane
- EC Number:
- 217-006-6
- EC Name:
- Chloro(chloromethyl)dimethylsilane
- Cas Number:
- 1719-57-9
- Molecular formula:
- C3H8Cl2Si
- IUPAC Name:
- chloro(chloromethyl)dimethylsilane
- Test material form:
- other: colourless liquid
- Details on test material:
- Purity 99.4% (GC)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cri: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 6 male and three female animals
Body weight (at start of administration): male 192 - 251 g, female 185 - 193 g
Age (at start of adaptation): male 41 days, female 53 days
Identification of animals: by coloured marks and cage labels
Duration of experiment: at least 5 adaptation days, 1 test day, 2 recovery weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: The test substance was used as supplied for the highest dose level of 2000 mg/kg body weight. Corn oil was used as vehicle for the second dose level of 200 mg/kg body weight.
- Details on oral exposure:
- The test substance was used as supplied for the highest dose level of 2000 mg/kg
body weight. Corn oil was used as vehicle for the second dose level of 200 mg/kg
body weight.
Administration volume: 1.84 mL/kg b.w. - Doses:
- 2000 mg/kg b.w.
200 mg/kg b.w. - No. of animals per sex per dose:
- Order of administration
1) 2000 mg/kg b.w., male animals
2) 200 mg/kg b.w., male animals
3) 200 mg/kg b.w.,female animals - Control animals:
- yes
- Details on study design:
- Feeding was discontinued approx. 16 hours before administration; only tap water was then available ad libitum.
- Statistics:
- No statistical analysis was performed (The method used was not intended to allow the
calculation of a precise LD50 value).
Results and discussion
- Preliminary study:
- 2000 mg/kg b.w. resulted in the death within 3 hours of all male animals.
2000 mg/kg resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone, dyspnoea.
None of the six CD rats employed at 200 mg/kg b.w. died.
200 mg/kg in male animals resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone.
The three female animals at 200 mg/kg b.w. showed no signs of systemic toxicity.
2 of 3 surviving male animals gained the expected body weight within the study
period, one of 3 male animals showed a body weight reduction of 33.5%. All female
surviving animals gained the expected body weight within the study period.
Intestine inflated of all males at 2000 mg/kg body weight and in addition filled with
dark content of one male were found at macroscopic post mortem examination.
Caecum inflated of all males and females at 200 mg/kg body weight and in addition
intestine inflated of one male were also noted.
The oral LD50 value for Chlormethyl-dimethyl-chlorsilan in CD rats was ranked within
the LD50 range of 200 - 2000 mg/kg body weight.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No-effect dose level: <200 mg/kg b. w., by oral administration
Dose level with first intolerance reactions: 200 mg/kg b.w., by oral administration
Lowest lethal dose level: 2000 mg/kg b.w., by oral administration
LD50: 200 - 2000 mg/kg b.w., by oral administration - Clinical signs:
- 2000 mg/kg resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone, dyspnoea.
200 mg/kg in male animals resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone. - Body weight:
- 2 of 3 surviving male animals gained the expected body weight within the study
period, one of 3 male animals showed a body weight reduction of 33.5%. All female
surviving animals gained the expected body weight within the study period. - Gross pathology:
- Intestine inflated of all males at 2000 mg/kg body weight and in addition filled with
dark content of one male were found at macroscopic post mortem examination.
Caecum inflated of all males and females at 200 mg/kg body weight and in addition
intestine inflated of one male were also noted.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- According to the EC-Commission directive 67/548/EEC and its subsequent
amendments on the approximation of the laws, regulations and administrative
provision relating to the classification, packaging and labelling of dangerous
substances and the results obtained under the present test conditions
Chlormethyl-dimethyl-chlorsilan has to be classified as harmful
(200 mg/kg < LD50 < 2000 mg/kg). - Executive summary:
2000 mg/kg b. w. resulted in the death within 3 hours of all male animals.
2000 mg/kg resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone, dyspnoea.
None of the six CO® rats employed at 200 mg/kg b.w. died.
200 mg/kg in male animals resulted following signs of systemic toxicity:
reduced motility, ataxia, reduced muscle tone.
The three female animals at 200 mg/kg b.w. showed no signs of systemic toxicity.
2 of 3 surviving male animals gained the expected body weight within the study
period, one of 3 male animals showed a body weight reduction of 33.5%. All female
surviving animals gained the expected body weight within the study period.
Intestine inflated of all males at 2000 mg/kg body weight and in addition filled with
dark content of one male were found at macroscopic post mortem examination.
Caecum inflated of all males and females at 200 mg/kg body weight and in addition
intestine inflated of one male were also noted.
The oral LD50 value for Chlormethyl-dimethyl-chlorsilan in CO® rats was ranked within
the LD50 range of 200 - 2000 mg/kg body weight.
According to the EC-Commission directive 67/548/EEC and its subsequent
amendments on the approximation of the laws, regulations and administrative
provision relating to the classification, packaging and labelling of dangerous
substances and the results obtained under the present test conditions
Chlormethyl-dimethyl-chlorsilan has to be classified as harmful
(200 mg/kg < LD50 < 2000 mg/kg).
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