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EC number: 204-062-1 | CAS number: 115-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Mild rhinitis has only been reported following lifetime exposure to high concentrations of propene gas.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Non-human
Mild rhinitis (mild nasal inflammation) was reported in rats following lifetime exposure to high concentrations of propene gas, 5000 ppm & 10,000 ppm, (8,600 & 17,200 mg/m3) (NTP, 1985; Harkema 2002). In contrast, no such effects were reported in nasal tissue from 14-day or 14-week studies in rats (NTP, 1985). Mice from the same NTP 2-year chronic toxicity study were reported to have similar effects, albeit with less epithelial alteration than rats (Harkema, 2002). There was no evidence of a clear dose-response relationship in either species, indeed the nasal effects were less pronounced at the higher dose level in male mice (Harkema, 2002). Subsequently, a 4-week investigative study, reporting nasal endpoints, failed to identify any inflammation, irritation or indeed any precursor proliferative event in rats exposed to up to 10,000 ppm (17,200 mg/m3) propene (Pottenger et al., 2007). The authors concluded that any irritant effect of propene must be extremely weak and that other factors may well have contributed. Overall, any irritant properties in rodents were mild in nature, lacking a clear dose-response relationship and reported only when high concentrations of propene gas were maintained throughout lifetime exposure.
Human
Although propene has been used in humans at concentrations sufficient to induce anaesthesia, there is only one literature report of potential adverse irritation effects associated with repeated induction of anaesthesia in one volunteer “After the first few breaths, there was usually slight reddening of the eyelids with some lacrimation and flushing of the eyes. Sometimes coughing would occur from pharyngeal irritation.” In this study, to efficiently induce anaesthesia, very high concentrations (688,000 – 861,000 mg/m3) of propene were rapidly introduced. This information is not considered useful in assessment of the irritation potential of propene gas, with its lower explosive limit of 34,000 mg/m3.
Justification for classification or non-classification
Any propene-induced rhinitis has been reported as mild in nature, occurring in rodents only after lifetime exposure to high concentrations (5,000ppm & 10,000ppm (8,600 and 17,200 mg/m3) of propene gas). This finding does not warrant classification for skin, eye, or respiratory tract irritation under DSD or CLP.
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