Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The estimated 14 day LC50 for earthworms is 103.1 mg/kg soil dw. TLM QSAR modelling was used to calculated LL50 and NOELR of isoprene towards E. fetida. The calculated LL50 values is 57.465 mg/kg soil dw and NOELR is 11.009 mg/kg soil dw.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 57.465 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 11.009 mg/kg soil dw
Additional information
Measured chronic data are not available for this endpoint. In the absence of measured data the ECOWIN v1 ECOSAR programme (Nabholz and Mayo-Bean 2009) is used to estimate a LC50 of 103.1 mg/kg dw soil for earthworms.
The ECOSAR model is a reliable and appropriate QSAR model to apply to isoprene as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis. The endpoint calculated here is therefore a reasonable estimate of its baseline toxicity. A QSAR prediction was used as the key endpoint in the OECD SIDS for isoprene (2005).
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