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Diss Factsheets
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EC number: 200-815-3 | CAS number: 74-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: QSAR calculation, reliable with restrictions
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- The Ecosar class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the Ecosar program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures, e.g., phenols. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.
- GLP compliance:
- not specified
- Remarks:
- Not applicable
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Not applicable - Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Details on test solutions:
- Not applicable
- Test organisms (species):
- other: fish
- Details on test organisms:
- Not applicable
- Test type:
- other: Not applicable
- Water media type:
- freshwater
- Total exposure duration:
- 30 d
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Conductivity:
- N/A
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Key result
- Duration:
- 30 d
- Dose descriptor:
- other: ChV
- Effect conc.:
- 12.385 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- calculated using the neutral organic QSAR. Data entered: log kow = 1.13, Melting point = -169.15°C, water solubility = 131 mg/l
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- not applicable
- Remarks:
- QSAR
- Conclusions:
- The predicted 30d ChV for ethylene was 12.385 mg/L.
- Executive summary:
The predicted 30d ChV for ethylene was 12.385mg/l. Measured data are not available for ethylene for this endpoint. Due to the practical difficulties associated with the ecotoxicity testing of gases (i.e. maintaining exposure concentrations) the use of QSAR toxicity estimates is an appropriate alternative. The ECOSAR model is a reliable and appropriate QSAR model to apply to ethylene as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis. The endpoint calculated here, 30 day ChV of 12.385 mg/L, is therefore a reasonable estimate of its baseline toxicity.
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The target lipid model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Key result
- Duration:
- 32 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 22.083 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- ChV (chronic value, QSAR)
- Conclusions:
- The estimated NOELR for this substance is 22.083 mg/L.
- Executive summary:
The long-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methodologies described by Mcgrath et al. (2015). The estimated NOELR for this substance is 22.083 mg/L.
Referenceopen allclose all
N/A
Description of key information
In the absence of measured data for fish, ECOSAR and TLM QSAR modelling was used to estimate the EC10 and NOELR. The estimated 21 -day ChV from ECOSAR QSAR is 12.39 mg/L and NOELR estimated from TLM QSAR is 22.083 mg/L.
The lowest value was used for the chemical safety assessment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 12.39 mg/L
Additional information
Ethylene is a gas at standard temperature and pressure and is expected to partition primarily to air, therefore aquatic toxicity tests may not be relevant. In addition, it is technically difficult to maintain aqueous concentrations of gases for toxicity testing.
Measured data are not available for ethylene for this endpoint. Due to the practical difficulties associated with the ecotoxicity testing of gases (i.e. maintaining exposure concentrations) the use of QSAR toxicity estimates is an appropriate alternative. Two QSAR models have been used to estimate the short term toxicity to fish:
ECOWIN v1 ECOSAR (Nabholz and Mayo-Bean 2009) calculated a 21 day ChV of 12.39 mg/L.
The Target Lipid Model (Mcgrath et al., 2004) calculated an NOELR of 22.083 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.