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Diss Factsheets
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EC number: 200-879-2 | CAS number: 75-56-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity data by oral, inhalation and dermal route indicate that propylene oxide is harmful by all routes. The studies for the oral and inhalation route were performed in rats comparable to the respective OECD guidelines 401 and 403, giving an oral LD50 of 382-587 mg/kg bw and an LC50 of 9.95 mg/L. For the dermal route data also indicate that PO is also harmful by this route, with an LD50 of 950 mg/kg bw (using rabbits).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 382 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 9 950 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 950 mg/kg bw
Additional information
Acute toxicity data from animal studies for oral, dermal, and inhalation exposure routes are available. The oral toxicity study was performed comparable to OECD guideline 401 in which 5 rats per sex per dose were used. From this study an LD50 range of 382-587 mg/kg bw was obtained (Shell Research Ltd., 1968). In the inhalation route study performed comparable to OECD guideline 403 (Shell Research Ltd., 1977), rats were whole-body exposed at 3000-5970 ppm, giving rise to an LC50 of 4197 ppm (9.95 mg/L). The dermal acute study predates GLP and OECD guidelines, but gives sufficient details to contribute to the assessments (Smyth et al., 1969). This study elicited a dermal LD50 of 1250 mg/kg.
Very limited acute toxicity information is reported for humans. A summary of a single case of poisoning reported that an individual exposed to 1500 ppm after 10 min exhibited respiratory tract and eye irritation and, after 2 hrs, became cyanotic and collapsed but with medical assistance recovered after 14 hrs (Gosselin, 1984). The EU RAR (2002) concluded this information to be questionably reliable due to lack of details on exposure.
Justification for classification or non-classification
According to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, 9th ATP - 19 July 2016, the classification is H331, Cat. 3, H311, Cat. 3 and H302, Cat. 4.
Classification as aspiration hazard is not warranted based on expert judgment of several physico-chemical properties ofpropylene oxide. Viscosity ofpropylene oxideis 0.374 mm2/s, which is below the cut-off value for aspiration. However, no cases in humans have ever been described. Based on this observation, as well as, other physicochemical properties, in particular high water solubility (>40%), classification as aspiration hazard is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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