Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol
EC number: 941-357-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The hydrolysis rate of the test substance is expected to be similar to other structural analogues derived from the reaction of epichlorohydrin with a bisphenol yielding such molecules as bisphenol A diglycidyl ether (BADGE; EINECS 216-823-5). Because of structural and hydrolytic mechanistic similarities, read-across from BADGE is appropriate to estimate the hydrolysis rate of the registered test substance.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Read-across to structurally similar analogue.
- GLP compliance:
- not specified
- Remarks:
- Not a formal hydrolysis study but read-across consideration. As such GLP provision not relevant.
- Specific details on test material used for the study:
- See attachment in 'attached full study report' for full details.
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.005 h-1
- DT50:
- ca. 110 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.008 h-1
- DT50:
- ca. 90 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.004 h-1
- DT50:
- ca. 170 h
- Type:
- (pseudo-)first order (= half-life)
- Conclusions:
- Because it is known that epoxides hydrolyse at rates which are independent of pH, the data from all three pH values for BADGE (the source substance) were combined. The result is half life = 117 h at 25°C (95% confidence range = 68 to 204 h).
See attachment in 'attached full study report' for full details on analogue approach and read-across methodology. - Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The hydrolysis rate of the test substance is expected to be similar to other structural analogues derived from the reaction of epichlorohydrin with a bisphenol yielding such molecules as bisphenol A diglycidyl ether (BADGE; EINECS 216-823-5). Because of structural and hydrolytic mechanistic similarities, read-across from BADGE is appropriate to estimate the hydrolysis rate of the registered test substance.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
[Describe why the read-across can be performed (e.g. common functional group(s), common precursor(s)/breakdown product(s) or common mechanism(s) of action]: See attachment in 'attached full study report' for full details.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
[Provide here, if relevant, additional information to that included in the Test material section of the source and target records]: See attachment in 'attached full study report' for full details.
3. ANALOGUE APPROACH JUSTIFICATION
[Summarise here based on available experimental data how these results verify that the read-across is justified]: See attachment in 'attached full study report' for full details.
4. DATA MATRIX: Not required; based on structural properties and known chemistry. Also, read-across only used for environmental fate (hydrolysis) endpoint, and not human health or ecotoxicology. - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across to structurally similar analogue.
- GLP compliance:
- no
- Remarks:
- Not a formal hydrolysis study but read-across consideration. As such GLP provision not relevant.
- Specific details on test material used for the study:
- See attachment in 'attached full study report' for full details.
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.005 h-1
- DT50:
- ca. 110 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.008 h-1
- DT50:
- ca. 90 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.004 h-1
- DT50:
- ca. 170 h
- Type:
- (pseudo-)first order (= half-life)
- Conclusions:
- Because it is known that epoxides hydrolyse at rates which are independent of pH, the data from all three pH values for BADGE (the source substance) were combined. The result is half life = 117 h at 25°C (95% confidence range = 68 to 204 h).
See attachment in 'attached full study report' for full details on analogue approach and read-across methodology.
Referenceopen allclose all
Description of key information
Read-across has been used to the analogous substance BADGE, for which hydrolysis as a function of pH data are available.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 117 h
- at the temperature of:
- 25 °C
Additional information
Bisphenol A Diglycidyl Ether (BADGE; CASN 1675-54-3) is consistently used for read-across to estimate hydrolysis as a function of pH for all EINECS diglycidyl ethers derived from bisphenols that are reacted with epichlorohydrin. The hydrolysis route for BADGE is mechanistically identical to hydrolysis of the target test substance. As epoxide hydrolysis occurs by nucleophilic substitution and does so at a rate that is independent of pH (as per BADGE), the data for all three pH levels were combined along with expert judgement, to provide the key value for chemical safety assessment (half-life = 117 h at 25°C (95% confidence range = 68 - 204 hr)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.