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EC number: 203-919-7 | CAS number: 111-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1999
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Published study with original report also available. However, no analytical monitoring available. The fact that no clear dose response relationship was seen, that the NOEC derived is extraordinarily low compared to the consistent acute EC50 data from a number of studies (factor of ~250) and that the confidence limits are huge (factor of 600 from lower to upper limit) means that this study is not regarded as being sufficiently reliable as a key study and is disregarded from the derivation of the PNEC
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- "Effects of|ethylene glycol ethers on the reproduction of Ceriodaphnia dubia."
- Author:
- DeVillers, J., A. Chezeau, et al. (2003).
- Year:
- 2 003
- Bibliographic source:
- Chemosphere 50: 373-376.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: draft AFNOR NF T90 - 376
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- yes
- Remarks:
- , different species. Only 7 days
- Principles of method if other than guideline:
- Note that the second reference, which is for a similar but different substance, contains some of the details of the methodology used that are reported here. Young organisms <24hrs old and from 2nd-5th brood of healthy adults are exposed to test solution.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethan-1-ol
- Details on test material:
- purity >= 99%;
Purchased from Sigma-Aldricht (Saint-Quentin Fallavier, France);
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Analytical monitoring was not carried out because preliminary tests showed that that concentrations remained stable (due to the low volatility) between the 24hr renewals.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Source: Laboratoire INERIS
- Age of parental stock (mean and range, SD): 7-14 days
- Feeding during test: Yes
- Food type: Chlorella vulgaris 6E6 cells/50ml; Raphidocelis subcapitata 3E6 cells/50ml; commercial fish food 5g/l
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7
Test conditions
- Hardness:
- 250 +/- 20 mg/L as CaCO3
- Test temperature:
- 25 +/- 2°C, monitored continuously.
- pH:
- ~8
- Dissolved oxygen:
- Disolved oxygen measured daily except weekends
- Nominal and measured concentrations:
- 5 concentrations, not specified. The highest concentration tested was the NOEC from acute toxicity studies using daphnia magna (see chapter 6.1.3)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: glass, 90ml size, 50ml fill.
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): daily, except weekends (either not day 1/2 or 2/3)
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates):
TEST MEDIUM / WATER PARAMETERS after aeration (typical)
- Source/preparation of dilution water: Evian mineral water
- Metals: 108mg/l (measured ions)
- Chloride: 4.5mg/l
- Ca 78mg/l
- Mg 24mg/l
- Na: 5mg/l
- K 1mg/l
- Sulphate 10mg/l
- Conductivity: 400 +/- 50uS/cm
- Hardness: 200mg CaCO3/l
- O2: >7mg/l
- pH: 8.3
OTHER TEST CONDITIONS
- Photoperiod: 16:8 light:dark photoperiod was employed
- Light intensity: (300-500 lux.);
- Test solutions renewed daily from day 3
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : parental mortality and number of offspring per alive parent (10% inhibition);
Results and discussion
Effect concentrations
- Duration:
- 7 d
- Dose descriptor:
- EC10
- Effect conc.:
- 7.38 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 0.14 - 89.21mg/l (95% CL)
- Results with reference substance (positive control):
- Sodium pentachlorophenate, copper(II) sulphate pentahydrate within normal ranges.
- Reported statistics and error estimates:
- EC values calculated using TOXSTAT v3.5 using Hill method. NOEC calculated using Bonferroni test
Any other information on results incl. tables
The 95% confidence interval is very wide, covering between 1 and 2 orders of magnitude.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- control survival >80%, less than 20% of males at day 7 per batch, >60% of control females had >=3 broods, control females producing an average of 15 offspring each by day 7. Reference compound results within historic ranges.
- Executive summary:
In a semi-static study carried out to an AFNOR protocol (similar to an OECD guideline study but shorter duration), Ceriodaphnia Dubai were exposed to 2 -(2 -ethoxyethoxy)ethanol for 7 days. An EC10 for reproduction of 7.38mg/l was established.
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