Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-858-8 | CAS number: 75-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- The skin
sensitisation potential of isopropyl chloride was assessed in a
GLP-compliant study performed according to OECD Guideline for the Testing
of Chemicals No. 406 (Fürst, 1989). In this study, the induction period
consisted of intradermal injections and an epicutaneous application. Three
pairs of intradermal injections (0.05 mL) were administered to the back of
Pirbright Dunkin Hartley guinea pigs (20 animals in the test group and 10
animals in the control group). The 3 injections were composed of the
following: 10% isopropyl chloride in vehicle (oleum arachidis), 10%
isopropyl chloride in Freund's Adjuvant complete (FCA), or undiluted FCA. The
control animals received the vehicle instead of the test compound. After 1
week, a single epicutaneous application of 0.5 mL isopropyl chloride
(0.75% in oleum arachidis) was applied for a period of 48 hours. During
the challenge period (2 weeks following epicutaneous application), 0.5 mL
of isopropyl chloride (75% in Oleum arachidis) was applied to the flank
for a period of 24 hours. Control animals were challenged with the vehicle
only. No sensitisation reactions were reported at 24 and 48 hours for the
test or control animals. It should be noted that the results of a recent
positive control test were not reported; however, the results of this test
are considered reliable. Therefore, the test compound isopropyl chloride
was considered not to cause contact hypersensitivity in guinea pigs.
Migrated from Short description of key information:
Isopropyl chloride was reported to be non-sensitizing to guinea pig skin in a sensitisation test, which was conducted in a GLP-compliant study and performed according to test guidelines.
Justification for classification or non-classification
There is no information available concerning respiratory sensitisation.
According to OECD TG 406 the submission substance is not a skin sensitizer. As a result, the substance does not meet the criteria for classification according to Regulation (EC) No 1272/2008, Annex I section 3.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.