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EC number: 233-020-5 | CAS number: 10022-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January 2013-21 February 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Barium nitrate
- EC Number:
- 233-020-5
- EC Name:
- Barium nitrate
- Cas Number:
- 10022-31-8
- Molecular formula:
- Ba(NO3)2
- IUPAC Name:
- barium nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): barium nitrate
- Substance type: white crystals
- Physical state: solid
- Analytical purity: 99.52 %
- Lot/batch No.: 120724
- Expiration date of the lot/batch: 2013-09-13
- Stability under test conditions: stable
- Storage condition of test material: Room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar strain Crl:WI (Han) (outbred, SPF-Quality).
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany.
- Age at study initiation: approx. 10 weeks old
- Weight at study initiation: 146-181g .Body weight variation did not exceed +/- 20% of the sex mean
- Fasting period before study: Overnight prior to dosing and until 3-4 hours after administration of the test substance.
- Housing: Group- 3 animals per cage- labeled Makrolon cages (MIV type; height 18 cm.) containing sterilized sawdust as bedding material (Litalabo, S.P.P.S., Argenteuil, France) and paper as cage-enrichment (Enviro-dri, Wm. Lillico & Son (Wonham Mill Ltd), Surrey, United Kingdom).
- Diet (e.g. ad libitum): Ad libitum-pelleted rodent diet (SM R/M-Z from SSNIFF® Spezialdiäten GmbH, Soest, Germany).
- Water (e.g. ad libitum): Ad libitum tap water.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 to 24°C
- Humidity (%): 40 to 70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
IN-LIFE DATES: From: 29 January 2013 To: 21 February 2013
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: varied depending on body weight
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: Selected based on trial formulations performed at WIL Research Europe and on test substance data supplied by the sponsor.
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg
DOSAGE PREPARATION (if unusual):To obtain homogeneity, the formulations were heated up to maximally 70 ºC for maximally 30 minutes. The formulations were allowed to cool down to maximally 40 ºC prior to dosing.
CLASS METHOD (if applicable): yes.
The toxicity of the test substance was assessed by stepwise treatment of groups of 3 females. The first group was treated at a dose level of 2000 mg/kg. The absence or presence of mortality of animals dosed at one step determined the next step, based on the test procedure defined in the guidelines. The onset, duration and severity of the signs of toxicity were taken into account for determination of the time interval between the dose groups. - Doses:
- 2000 mg/kg (10 mL/kg) body weight.
300 mg/kg (10 mL/kg) body weight.
50 mg/kg (10 mL/kg) body weight. - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At periodic intervals on the day of dosing (Day 1) and once daily thereafter, until Day 15. Body weights recorded at Day 1 and Day 15 (or death).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The three animals dosed at 2000 mg/kg were found dead within 2 hours post-dose. Two (of the three) animals dosed at 300 mg/kg were found dead on Days 1 or 3. No mortality occurred at 50 mg/kg.
- Clinical signs:
- other: At 2000 mg/kg no clinical signs were noted. At 300 mg/kg hunched posture, flat posture, lethargy, piloerection, uncoordinated movements, labored respiration, slow breathing were noted. At 50 mg/kg hunched posture, piloerection, uncoordinated movements, ch
- Gross pathology:
- Animals that were found dead had of the jejunum (several reddish foci) in one animal dosed at 2000 mg/kg and abnormalities of the stomach (several dark red foci at the glandular mucosa) and thymus (many dark red foci) in one animal dosed at 300 mg/kg. No test substance related macroscopic abnormalities were seen in the remaining animals found dead or in any of the surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The oral LD50 value of barium nitrate in rats was found to be in the range of 50-300 mg/kg body weight. According to the OECD 423 test guideline, the LD50 cut-off value was considered to be 300 mg/kg body weight. This value is used for risk assessment purposes.
Based on these results and according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2011), Barium Nitrate should be classified as: Toxic if swallowed (Category 3) for acute toxicity by the oral route. According to the Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, barium nitrate should be classified as Category 3 and should be labeled as H301: Toxic if swallowed.
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