Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-826-9 | CAS number: 100-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted using a documented method and in compliance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Stock solutions were prepared in flasks at a nominal concentration of 2 x 10"3 g/L in the three buffer solutions. A 5 % co-solvent of tetrahydrofuran was used to aid dissolution.
The stock solutions were split into individual vessels for each data point. The solutions were shielded from light whilst maintained at the test temperature. - Buffers:
- - pH: 4, 7 and 9
- composition of buffer, type and final molarity of buffer:
pH 4: Citiric acid (3.1 mmol dm-3), sodium cloride (2.2 mmol dm-3), sodium hydroxide (3.4 mmol dm-3)
pH 7: Disodium hydrogen orthophosphate (anhydrous) (1.5 mmol dm-3), pottasium dihydrogen orthophosphate (1 mmol dm-3), sodium chloride (1 mmol dm-3)
pH 9: Disodium tetraborate (0.5 mmol dm-3), sodium cloride (1 mmol dm-3) - Number of replicates:
- 2
- Transformation products:
- no
- % Recovery:
- >= 105 - <= 110
- St. dev.:
- 3.535
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 72 h
- % Recovery:
- >= 81 - <= 96
- St. dev.:
- 10.748
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- >= 105 - <= 106
- St. dev.:
- 0.707
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 72 h
- % Recovery:
- >= 100 - <= 107
- St. dev.:
- 4.95
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- >= 110 - <= 123
- St. dev.:
- 9.192
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 72 h
- % Recovery:
- >= 86.1 - <= 118
- St. dev.:
- 22.557
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated half-life at 25 °C of the test item at pH 4, pH 7 and pH 9 was shown to be greater than 1 year.
- Executive summary:
The estimated half-life at 25 °C of the test item at pH 4, pH 7 and pH 9 was shown to be greater than 1 year. Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
Reference
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0.5 to 20 mg/L. This was satisfactory with a correlation coefficient (r2) of 1.000 being obtained. Recovery of analysis of the sample procedure was assessed and proved adequate for the test. At a nominal concentration of 2 mg/L, a mean percentage recovery of 79.4 % was obtained (range 77.4 to 80.3 %). Concentrations have not been corrected for recovery of analysis.
Discussion
No significant peaks were observed at the approximate retention time of the test item on analysis of any matrix blank solutions. An initial attempt at the test had shown that a very small amount of the test item remained after 72 hours for all three pH's. From the chemical structure and physical parameters it was considered that the reduction in test item concentration was not due to hydrolysis but volatilisation. The test item, being a hydrocarbon, had no hydrolysable groups. The test was repeated with a higher percentage of co-solvent to help retain the test item in solution and with no headspace in the sealed sample vessels to minimalise the loss by volatilisation. Although after 120 hours samples pH 4A and pH 9B had reduced by more than 10 % compared to their averaged initial samples, it was considered that this was due to volatilisation as the sample vessels were later found to have a cracked base. It can even be seen with all samples that they were significantly lower than their "as weighed in concentration" and was also seen in the first attempt at the test. Overall, it was considered that the test item did not hydrolyse and had an estimated half-life of greater than 1 year at 25 °C for pH 4, pH 7 and pH 9.
Description of key information
Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The estimated half-life at 25 °C of the test item at pH 4, pH 7 and pH 9 was shown to be greater than 1 year.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Assessment of hydrolytic stability was carried out using a procedure designed to be compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The estimated half-life at 25 °C of the test item at pH 4, pH 7 and pH 9 was shown to be greater than 1 year.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.