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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 455-890-7 | CAS number: 6607-41-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 21.16 mg/m³
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.48 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- There are no relevant experimental data on repeated exposure by inhalation.
- AF for dose response relationship:
- 1
- Justification:
- A NOAEL is used as starting point.
- AF for differences in duration of exposure:
- 1
- Justification:
- Effect level is based on a reproduction study and can therefore be considered to be chronic.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Respiratory interspecies differences are fully covered by the factors used for route to route extrapolation.
- AF for other interspecies differences:
- 2.5
- Justification:
- The ECHA REACH TG default value was used for remaining differences.
- AF for intraspecies differences:
- 5
- Justification:
- The ECHA REACH TG default value for the relatively homogenous group "worker" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient.
- AF for remaining uncertainties:
- 1
- Justification:
- No further assessment factors are required.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- There are no relevant experimental data on the systemic effects as a results of dermal exposure.
- AF for dose response relationship:
- 1
- Justification:
- A NOAEL is used as starting point.
- AF for differences in duration of exposure:
- 1
- Justification:
- Effect level is based on a reproduction study and can therefore be considered to be chronic.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The ECHA REACH TG default allometric scaling factor for the interspecies differences.
- AF for other interspecies differences:
- 2.5
- Justification:
- The ECHA REACH TG default value was used for remaining differences.
- AF for intraspecies differences:
- 5
- Justification:
- The ECHA REACH TG default value for the relatively homogenous group "workers" is used.
- AF for the quality of the whole database:
- 1
- Justification:
- The quality of the whole data base is considered to be sufficient.
- AF for remaining uncertainties:
- 1
- Justification:
- No further assessment factors are required.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
Acute exposure – workers
Acute / short-term exposure – local and systemic effects
- Dermal: The DNEL acute dermal does not appear relevant for Risk Characterisation - no acute local or systemic effects are anticipated.
- Inhalation: The DNEL acute inhalation does not appear relevant for Risk Characterisation - no acute local or systemic effects are anticipated.
Long-term exposure – workers
Long-term exposure – local and systemic effects
Dermal long-term systemic:
For dermal the NOAEL of 300 mg/kg bw/day was not adjusted for route to route extrapolation assuming that dermal absorption will not be higher than oral absorption. Therefore the point of departure is 300 mg/kg. This is then divided by a factor 4 for allometric scaling from rat to human multiplied by, the additional factor for interspecies differences of 2.5, the assessment factor intra-species variability for worker of 5, the factor for duration is 1 (as the end point on which the 300 mg/kg is based is for developmental toxicity and therefore not influenced the duration of the study). The factor for the quality of the data was 1. So this gives 300 / (4* 2.5 * 5 * 1* 1) = 6 mg/m3.
Inhalation long-term systemic:
For inhalation the NOAEL of 300 mg/kg bw/day was adjusted for the difference in respiration rate relative to bodyweight from rats to humans. For workers this gives a NOAEC of 300 * (1/0.38) * (6.7/10) = 528.95 mg/m3. This NOAEC is divided by 2 (ECHA factor to extrapolate from oral to inhalation) to give a point of departure of 264.48 mg/m3. This is then divided by the additional factor for interspecies differences of 2.5 multiplied by the assessment factor intra-species variability for worker of 5, the factor for duration is 1 (as the end point on which the 300 mg/kg is based is for developmental toxicity and therefore not influenced the duration of the study). The factor for the quality of the data was 1. So this gives 264.48 / (2.5 * 5 * 1* 1) = 21.16 mg/m3.
Inhalation and dermal long-term local:
The DNEL long-term local, dermal and inhalation cannot be derived as no long-term data is available for these routes.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
No exposure to general population expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.