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EC number: 231-633-2 | CAS number: 7664-38-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 13 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- Study only concerns one registrant
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Inspection: 13 to 15 October 2015 Date of Signature on Certificate: 13 January 2016
- Other quality assurance:
- other: ISO 13320:2009; CIPAC MT 187
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- Molecular formula:
- H3O4P
- IUPAC Name:
- phosphoric acid
- Details on test material:
- - Name of test material (as cited in study report): phosphoric acid
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Smiles notation (if other than submission substance): not applicable
- InChl (if other than submission substance): not applicable
- Structural formula attached as image file (if other than submission substance): not applicable
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: not applicable
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Radiochemical purity (if radiolabelling): not applicable
- Specific activity (if radiolabelling): not applicable
- Locations of the label (if radiolabelling): not applicable
- Expiration date of radiochemical substance (if radiolabelling): not applicable
- Stability under test conditions: no data
- Storage condition of test material: no data
- Other: no data
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- 15.639 µm
- St. dev.:
- 0.066
- Percentile:
- D50
- Mean:
- 30.449 µm
- St. dev.:
- 0.168
- Percentile:
- D90
- Mean:
- 187.036 µm
- St. dev.:
- 3.841
Any other information on results incl. tables
Standard visual observation
Sample observed to be a polydispersed , colourless crystalline solid with lumps and clusters.
Observation using 3.2 objective lens
The particles appeared to be irregular shaped crystals. The smallest individual particle size was approximately 6.4 μm and the largest individual size was approximately 144.0 μm.
Observation using 40 objective lens
The sample was observed to be made up of single crystalline particles with some agglomerations present.
Laser Diffraction Particle Size Analysis
Date : 26/07/2017
Operator : G. Jordan
Preparation : Sample tested as received
SOP Reference : CTL SOP No. 417
During the method development phase of the analysis trials were conducted using the small volume (wet) module (SVM) due to the sample being hygroscopic. The results of these trials indicated that the most appropriate test and material parameters to obtain the optimum measurements were:
Module : SVM
Dispersant : Silicone Oil
Dispersion speed : 2300 rpm
Refractive index (sample) : 0.000 n
Absorption : 5e-005 AU
Analysis Model : General Purpose (Normal)
Using the identified parameters, the particle size was analysed over the range 0.02 μm to 2000 μm. The results of the formal analysis are presented in Table 9:1. In addition, a graph of volume (%) versus Particle Diameter (μm), and full particle size distribution, is provided in Graph 9.A (Average of 5 runs).
The table of results can be found below:
Table 9.1: Full Test Results
|
RUN 1 |
RUN 2 |
RUN 3 |
RUN 4 |
RUN 5 |
Average* |
Volume weighted mean |
58.301 |
59.314 |
60.064 |
61.088 |
62.191 |
60.192 |
Median |
30.240 |
30.328 |
30.419 |
30.557 |
30.714 |
30.449 |
Mode |
27.109 |
29.946 |
26.844 |
26.795 |
26.672 |
26.873 |
d10 – 10% of material is < |
15.558 |
15.584 |
15.624 |
15.708 |
15.723 |
15.639 |
d50 – 50% of material is < |
30.240 |
30.328 |
30.419 |
30.557 |
30.714 |
30.449 |
d90 – 90% of material is < |
181.508 |
184.538 |
189.611 |
189.611 |
192.504 |
187.036 |
All results are in µm
*Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
0.69% by volume of sample was seen to be < 10.00 µm
Table 9.2: Standard Deviation results
Run No |
1 |
2 |
3 |
4 |
5 |
STDVP |
%STDVP |
d10 – 10% of material is < |
15.558 |
15.584 |
15.624 |
15.708 |
15.723 |
0.066 |
0.4 |
d50 – 50% of material is < |
30.240 |
30.328 |
30.419 |
30.557 |
30.714 |
0.168 |
0.6 |
d90 – 90% of material is < |
181.508 |
184.538 |
189.611 |
189.611 |
192.504 |
3.841 |
2.1 |
d15.78 – 15.78% of material is < |
17.764 |
17.874 |
17.821 |
17.900 |
17.919 |
0.062 |
0.3 |
GSD |
1.702 |
1.705 |
1.707 |
1.707 |
1.714 |
0.004 |
0.2 |
GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78)
STDVP = standard deviation of the population
% STDVP = percentage standard deviation of the population
Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of
the characteristic particles in the size distribution are within the acceptable limits as per the ISO
13320-1 test standard.
Applicant's summary and conclusion
- Conclusions:
- The average particle sizes were as follows:
d10 - 15.639 μm
d50 - 30.449 μm
d90 - 187.036 μm - Executive summary:
Laser diffraction was used to determine the particle size distribution of phosphoric acid. The sample is initially observed to determine whether sieving of the material is required. A method development for the particle size analysis on the material is then undertaken
to obtain the correct parameters for the formal analysis. The method development is employed to identify the most appropriate optical properties for the material, the correct dispersant, dispersion pressures and sample compatibility. Once these parameters are obtained the final
sample is then analysed using the Malvern Mastersizer 2000 Laser Diffraction Analyser. 5 runs are completed to ensure repeatability of results. The test is conducted in accordance with ISO 13320:2009 and CIPAC MT 187.
Due to the powder being hygroscopic, the analysis was carried out using the ‘wet’, small volume dispersion system.
The results of the laser diffraction test conducted to determine the particle size of Phosphoric Acid 99% Crystalized are summarised in the table below. The analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.
Particle Size Analysis using small volume (wet) module (SVM).
Average*
Volume weighted mean
60.192
Median
30.449
Mode
26.873
d10 – 10% of material is <
15.639
d50 – 50% of material is <
30.449
d90 – 90% of material is <
187.036
volume of sample <10.00 µm
0.69%
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