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EC number: 273-760-6 | CAS number: 69012-63-1 By-product of refining of zinc ores consisting primarily of zinc, lead and iron.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and scientifically good . Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute dermal toxicity
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Flue dust, zinc-refining
- EC Number:
- 273-760-6
- EC Name:
- Flue dust, zinc-refining
- Cas Number:
- 69012-63-1
- Molecular formula:
- Not applicable - UVCB
- IUPAC Name:
- Zinc oxide enriched flue dust
- Details on test material:
- name: Probe B Wälzoxid B.U.S. Zinkrecycling Freiberg GMBH
description: grey dust
batch number: 02.07.99
expiry date: for at least one year
stability of test article: not specified
stability of test article dilution: not specified
storage conditions: at room temp (17-23°C) away from direct sunlight
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd Biotechnology and Animal Breeding Division CH-4414 Füllinsdorf/Switserland
- Age at study initiation: 9 weeks for males, 12 weeks for females
- Weight at study initiation: no information
- Housing: Makrolon type-3/-4 cages
- Diet: pelleted standard Kliba 3433, batch nos 37/99 and 39/99, rat maintenance diet (Kliba Mühlen AG, CH-4303 Kaiseraugst ad libitum
- Water: community tap water from Itingen ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: backs of the animals
- % coverage: 10% of the total body surface
- Type of wrap if used: semi-occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin was flushed with lukewarm tap water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): application volume/kg body weight: 4.0ml
- Concentration (if solution): 0.5g/ml
- Constant volume or concentration used: yes
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
mortality/viability: 4 times during test day 1 and once daily during days 2-15
body weights: on test day1 (pre-administration) , 8 and 15
clinical signs: each animal was examined for changes in appearance and behaviour four times during day 1 and once daily during days 2-15 - Statistics:
- No statistical analysis was used as no deaths occured
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occured during the study
- Clinical signs:
- other: No systemic or local signs of toxicity were observed during the study period
- Gross pathology:
- No macroscopic findings were observed at necroscopy
- Other findings:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute dermal toxicity
- Executive summary:
The purpose of this study was to assess the acute dermal toxicity of PROBE B Wälzoxid B.U.S. Zinkrecycling Freiberg GMBH when administered to rats by a single semi-occlusive dermal application, followed by an observation period of 14 days.
This dermal acute toxicity test according to OECD 402 with 2000mg/kg bw application of Waelz zinc oxide demonstrated that the LD50 for rats was > 2000mg/kg bw
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