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EC number: 203-564-8 | CAS number: 108-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP compliant, near guideline study, available as unpublished report, adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- 5 animals per gender per group
Starved for 16 hours before administration of the test material.
Single oral gavage administration
Seven dose levels.
Animals monitored over 14 days.
Autopsy of animals that died during study
Survivors sacrificed at study termination, then autopsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- SPF-bred: WIGA, Sulzfeld
mean staring weight males = 254g
mean starting weight females = 190g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Remarks:
- Emulsion in olive oil
- Details on oral exposure:
- formulated from 3.16 - 31.6 % in olive oil.
- Doses:
- 316, 464, 681, 1000, 1470, 2150, 3160 mg/kg bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- 5 animals per gender per group. Single oral dose using 7 dose levels .
Animals monitored over 14 days and symtoms and deaths recorded at 1 hour, 24 hours, 48 hours, 7 days and 14 days post dose.
At the end of the 14 days the animals were killed following exposure to CO2 prior to examination of major internal organs.
Animals that died during the study were autopsied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 630 mg/kg bw
- Mortality:
- Death usually occurred within 24 hours of dosing.
- Clinical signs:
- other: Toxic signs included dyspnoea. apathy, lying down, staggering, shaking, trembling, diarrhoea, hypertension, arched back and general poor condition.
- Gross pathology:
- Animals that died during the study - heart: acute dilation; acute inflamation. Stomach: hardened lining and bloody ulceration. GI tract with redenned membranes.
Surviving animals - Stomach: ulcerative spots. Adhesions of the forestomach, liver, spleen, diaphram and peritoneum.
Any other information on results incl. tables
Mortality
Dose |
Concentration
|
Number of Animals |
Mortality within |
||||
mg/kg |
% |
|
1 hour |
24 hours |
48 hours |
7 days |
14 days |
3160 |
31.6 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
|
|
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
2150 |
21.5 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
|
|
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
1470 |
14.7 |
5 male |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
|
|
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
1000 |
10 |
5 male |
0/5 |
3/5 |
3/5 |
3/5 |
3/5 |
|
|
5 female |
0/5 |
3/5 |
3/5 |
3/5 |
3/5 |
681 |
6.81 |
5 male |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
|
|
5 female |
0/5 |
5/5 |
5/5 |
5/5 |
5/5 |
464 |
4.64 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
|
5 female |
0/5 |
1/5 |
1/5 |
1/5 |
2/5 |
316 |
3.16 |
5 male |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
|
|
5 female |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
- Executive summary:
The LD50 of acetic anhydride in rats was estimated to be 630 mg/kg bodyweight following oral, gavage, administration of the test material.
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