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EC number: 232-051-1 | CAS number: 7784-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, according to accepted guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Aluminium fluoride
- EC Number:
- 232-051-1
- EC Name:
- Aluminium fluoride
- Cas Number:
- 7784-18-1
- Molecular formula:
- AlF3
- IUPAC Name:
- aluminum trifluoride
- Details on test material:
- - Name of test material (as cited in study report): aluminum trifluoride (CAS # 07784-18-1)
- Physical state: solid
- Analytical purity: 90%
- Lot/batch No.: reported as July 2004 (date of production)
- Stability under test conditions: until 31-12-2008
- Storage condition of test material: ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Deutschland, Sulzfeld, Germany
- Age at study initiation: 6 weeks old
- Weight at study initiation: not reported
- Fasting period before study: none
- Housing: in conventional conditions in macrolon cages with a bedding of wood shavings, 5 rats/cage, separated by sex
- Diet (e.g. ad libitum): commercial rodent diet (Rat and Mouse No. 3 breeding diet RM3) available ad libitum
- Water (e.g. ad libitum): tap water ad libium
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/- 3
- Humidity (%): 70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: MMAD were 1.2, 1.6, and 1.7 micrometers for the low, mid and high dose, respectively. The GSD were 3.7, 3.1, and 3.7 for the low, mid and high dose, respectively.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: each unit consisted of a cylindrical column, surrounded by a transparent cylinder. The column had a volume of 50 L and consisted of a top assembly with the inlet of the test atmosphere, a rodent tube section and at the bottom, the base assembly with the exhaust port.
- Method of holding animals in test chamber: each rodent tube had 20 ports for animal exposure and the animals were secured in plastic animal holders
- Temperature, humidity, pressure in air chamber: The temperature and relative humidity of the test atmospheres were measured with an RH/T device
VEHICLE (if applicable)
-Not applicable - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The empty ports in the unit were used for measurements of concentrations.
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 6 hours/day for 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1, 7, and 50 mg/m3
Basis:
analytical conc.
- No. of animals per sex per dose:
- 5 sex/dose
- Control animals:
- yes, sham-exposed
- Details on study design:
- - Dose selection rationale: based on preliminary study
- Rationale for animal assignment (if not random): random - Positive control:
- none
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: maximum 3 times on weekdays and once/day on weekends
DETAILED CLINICAL OBSERVATIONS: No
BODY WEIGHT: Yes
- Time schedule for examinations: once during acclimation period, one day before exposure period, at initaion of treatment, weekly thereafter, and once before sacrifice
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: Yes
WATER CONSUMPTION: No
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
- Time schedule for collection of blood: at necropsy
- Anaesthetic used for blood collection: Yes; nembutal
- Animals fasted: Yes
- How many animals: all
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: at necropsy
- Animals fasted: Yes
- How many animals: all
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- None
- Statistics:
- One way ANOVA with Dunnets multiple comparison tests. Kruskal-Wallis non-parametric ANOVA followed by Mann-Whitney U tests.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- no effects observed
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- HAEMATOLOGY
-Red blood cell concentration was significantly increased in females of the mid concentration group, which was not considered to be related to treatment. In males, the concentration of neutrophils was significantly increased in the high-dose group.
CLINICAL CHEMISTRY
-The albumin/globulin ratio in plasma was significantly decreased in male animals in the high concentration group, not considered to be related to treatment.
ORGAN WEIGHTS
- Increase in absolute and relative lung weights of males and females in the high dose group. Increase in absolute and relative liver weight in high dose males. Increase in absolute and relative heart weight of mid dose males, which was not considered to be related to treatment.
HISTOPATHOLOGY: NON-NEOPLASTIC
- Changes in lungs of all animals and in tracheobronchial lymph nodes of males and females in the high-concentration group. In lungs of high dose animals, multifocal alveolar pigment macrophages with particulate material in their cytoplasm was accompanied by inflammatory changes.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 7 mg/m³ air (analytical)
- Sex:
- male/female
- Basis for effect level:
- other: Significant changes in organ weights and histopathological changes in the lungs of high dose animals.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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