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EC number: 200-579-1 | CAS number: 64-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Potassium diformate did not show potential for carcinogenicity in two valid long-term rodent feed studies at 2000 mg/kg bw/day. This can be extrapolated to formic acid.
Key value for chemical safety assessment
Justification for classification or non-classification
Potassium diformate (1:2) did not show potential for carcinogenicity in two long-term rodent feed studies. This can be extrapolated to formic acid and other formate salts.
Additional information
There are two combined oral feed chronic toxicity and oncogenicity studies on potassium diformate (1:2) known to exist. These tests include the combined 104-week chronic toxicity and oncogenicity rat study (50 Crl:HanWist(Glx:BRL)BR rats/sex/concentration at concentrations of 0, 50, 400, and 2000 mg/kg bw/day) and the combined oral feed 80-week chronic toxicity and oncogenicity mouse study (51 Crl:CD-1 (ICR)BR mice/sex/concentration at concentrations of 0, 50, 400, and 2000 mg/kg bw per day). The pattern of mortality did not indicate any treatment-related effect in either the rat or mouse. The spectrum of tumours was generally consistent with that expected in rats or mice of these strains. There were no tumours of unusual nature or incidence indicative of specific target organ carcinogenicity in the stomach or any other tissue at any concentration level in any species or sex.The NOAEL for carcinogenicity was 2000 mg potassium diformate/kg bw/day in both sexes. This dose is equivalent to 708 mg formic acid/kg bw/day, or 1415 mg formate anion/kg bw/day.
Potassium diformate (1:2) did not show potential for carcinogenicity in two long-term rodent feed studies. This result can be extrapolated to formic acid and the other formate salts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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