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Diss Factsheets
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EC number: 204-781-0 | CAS number: 126-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitizing potential of Neopentylglycol was assessed using the radioactive Murine Local Lymph Node Assay (OECD 429). Groups of 5 female CBA/J mice each were treated with a 60% w/w preparation of the test substance in propylene glycol or with the vehicle alone. The test substance showed no increase in the 3H-thymidine incorporation, auricular lymph node cell counts or lymph node weights and did not cause any increase in ear weights. Thus it is concluded that Neopentylglycol does not show a skin sensitizing effect in the Murine Local Lymph Node Assay under the test conditions chosen.
Furthermore, there are studies available for structural similar compounds as 1,2 -propanediol (57-55-6) or isopropanol (67-63-5).
In a epicutaneous sensitization study no skin reaction was seen in 20 guinea pigs exposed to 1,2-propanediol (57-55-6) in the challenge application. The study was conducted similar to OECD 406. Acclimatization of the animals was 1 week followed by intradermal induction (first week) , dermal induction (3 applications per week for 2 weeks) and one week rest. Challenge application was on day 28. Challenge readings of the treated area are made 1, 6, 24 and 48 h after removing the patch.
Neopentylglycol was also predicted to be non-sensitizing by the OECD Toolbox on the basis of data available for isopropanol (67-63-5).
Migrated from Short description of key information:
Neopentylglycol does not show a skin sensitizing effect in the Murine Local Lymph Node Assay (OECD 429). In a short communication of a product information sheet (no details available) it is mentioned that repeated application to the guinea pig skin did not result in skin sensitization. Beyond this, there is no hint for any sensitizing property for animal studies available for structural related substances (isopropyl alcohol see QSAR; 1,2 propandiol see read across substance).Consequently Neopentylglykol is considered non sensitizing to the skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
As Neopentylglycol was found to be non-sensitizing to the skin it is supposed to be non sensitizing to the respiratory tract as well.
Justification for classification or non-classification
Classification is not warranted. The criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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