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EC number: 270-112-4 | CAS number: 68411-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 03.05.2018 – 26.06.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- assessment report
- Reason / purpose for cross-reference:
- read-across: supporting information
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Hydrolysis of benzoic acid esters was determined and evaluated as described in the EFSA guidelines “Note for Guidance for Food Contact Materials.”
- GLP compliance:
- no
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 03.05.2018 – 26.06.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- assessment report
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Hydrolysis of benzoic acid esters was determined and evaluated as described in the EFSA guidelines “Note for Guidance for Food Contact Materials.”
- GLP compliance:
- no
- Conclusions:
- Benzoic acid, C12-15-alkyl ester is a colourless liquid with a low vapour pressure value suggesting low potential for inhalative exposure. The Partition coefficient n-octanol/water suggests potential for bioaccumulation. The physico-chemical properties and the lack of effects observed in acute dermal and inhalation studies confirm that Benzoic acid, C12-15-alkyl ester is not absorbed to a significant degree via the dermal or inhalation route of exposures. After oral take up and intestinal absorption, the test item will be hydrolysed by cleavage of the ester bond and then further metabolized. Slightly elevated liver weights after high dose exposure are indicative of an increased liver metabolism. High dose effects further demonstrate that some systemic distribution takes place. The rather low toxicity observed in repeated dose studies indicates that the test item is unlikely to exert adverse effects by dose accumulation. This is further supported by the fast degradation of the test item in biodegradation studies in which bacteria and single-cell eucaryotes demonstrated mineralisation of the test item to a degree that qualifies the test item to be readily biodegradable. Thus it is highly unlikely that the test item will bioaccumulate.
- Executive summary:
Benzoic acid, C12-15-alkyl esteris a colourless liquid with a low vapour pressure value suggesting low potential for inhalative exposure. The Partition coefficient n-octanol/water suggests potential for bioaccumulation.The physico-chemical properties and the lack of effects observed in acute dermal and inhalation studies confirm that Benzoic acid, C12-15-alkyl ester is not absorbed to a significant degree via the dermal or inhalation route of exposures. After oral take up and intestinal absorption, the test item will be hydrolysed by cleavage of the ester bond and then further metabolized. Slightly elevated liver weights after high dose exposure are indicative of an increased liver metabolism. High dose effects further demonstrate that some systemic distribution takes place. The rather low toxicity observed in repeated dose studies indicates that the test item is unlikely to exert adverse effects by dose accumulation. This is further supported by the fast degradation of the test item in biodegradation studies in which bacteria and single-cell eucaryotes demonstrated mineralisation of the test item to a degree that qualifies the test item to be readily biodegradable. Thus it is highly unlikely that the test item will bioaccumulate.
Referenceopen allclose all
Purity
Sample 1 shows benzoic acid esters, the derivatization showed no by-products like alcohols or acids.
Hydrolysis with gastric-fluid simulant
The hydrolysis rates in acidic medium after 2 hours for the benzoic acid esters are 30-40%. The degradation rate of the sum of all isomers of the benzoic acid esters is about 35%.
Hydrolysis with intestinal-fluid simulant
In low alkaline-enzyme medium all detected esters in sample 1 indicates a continuously degradation. The hydrolysis rates after 4 hours for the benzoic acid esters are 50-70%. The degradation rate of the sum of all isomers of the benzoic acid esters is about 62%.
Mass balance
Because of the not identified structures of almost all esters present in the solution there is no possibility for the calculation of the mass balance.
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Purity
Sample 2 shows benzoic acid esters, the derivatization showed dodecanol, tridecanol, tetradecanol and pentadecanol as by-products .
Hydrolysis with gastric-fluid simulant
The hydrolysis rates in acidic medium after 2 hours for the benzoic acid esters are 25-30%. The degradation rate of the sum of all isomers of the benzoic acid esters is about 27%.
Hydrolysis with intestinal-fluid simulant
In low alkaline-enzyme medium all detected esters in sample 2 indicates a continuously degradation. The hydrolysis rates after 4 hours for the benzoic acid esters are 40-55%. The degradation rate of the sum of all isomers of the benzoic acid esters is about 40%.
Mass balance
Because of the not identified structures of almost all esters present in the solution there is no possibility for the calculation of the mass balance.
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Description of key information
Benzoic acid, C12-15-alkyl ester is a colourless liquid with a low vapour pressure value suggesting low potential for inhalative exposure. The Partition coefficient n-octanol/water suggests potential for bioaccumulation. The physico-chemical properties and the lack of effects observed in acute dermal and inhalation studies confirm that Benzoic acid, C12-15-alkyl ester is not absorbed to a significant degree via the dermal or inhalation route of exposures. After oral take up and intestinal absorption, the test item will be hydrolysed by cleavage of the ester bond and then further metabolized. Slightly elevated liver weights after high dose exposure are indicative of an increased liver metabolism. High dose effects further demonstrate that some systemic distribution takes place. The rather low toxicity observed in repeated dose studies indicates that the test item is unlikely to exert adverse effects by dose accumulation. This is further supported by the fast degradation of the test item in biodegradation studies in which bacteria and single-cell eucaryotes demonstrated mineralisation of the test item to a degree that qualifies the test item to be readily biodegradable. Thus it is highly unlikely that the test item will bioaccumulate.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
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