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EC number: 202-423-8 | CAS number: 95-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: NEN 6501 (1976): Toxicity test to Daphnia sp.
- Principles of method if other than guideline:
- The sensitivity of Daphnia magna in short-term tests has been tested in comparison with Daphnia pulex and Daphnia cucullata. Additionally, the reproducibility of the method was tested.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- The daphnids were cultured as described by ten Berge (1978). The short-term (LC50.48 h) and reproduction toxicity experiments with Daphnia magna were carried out in analogy to the concept rules of the Dutch Standardization Institute (Adema, 1978); the short-term tests
with Daphnia pulex and Daphnia cucullata in the same way as the experiments with Daphnia magna. The age of Daphnia cucullata however deviated: instead of animals < 1 day, 11 ± 1 day old organisms were used in view of the required size. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 +/- 1°C
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Remarks:
- Daphnia magna
- Effect conc.:
- 15.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Overall Mean value
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Remarks:
- Daphnia pulex
- Effect conc.:
- 9.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Mean value
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Remarks:
- Daphnia cucullata
- Effect conc.:
- 16.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Mean value
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The acute toxicity of o-cresol to Daphnia pulex was determined in 3 different laboratories. The tests were carried out according to a Dutch standard method which is similar to OECD 202 . The lowest mean-value for the 48h-EC50 of 1 laboratory was reported to be 9.6 mg/l.
- Executive summary:
The acute toxicity of o-cresol to Daphnia pulex was determined in a static immobilization test after an exposure period of 48 h. The test was carried out in analogy to a Dutch standard method which is similar to OECD 202. In 3 laboratories, duplicate samples with each 25 individuals of <1 day old daphnids were exposed to the test solutions. Analytical confirmation of exposure levels was not performed. The lowest nominal EC50 was reported to be 9.6 mg/l.
Reference
The single results (48h-LC50 in mg/l) of each test and laboratory are shown in the table:
Daphnia magna | Daphnia pulex | Daphnia cucullata | |
Lab I | 9.8 | 10.8 | |
8.6 | 8.5 | ||
mean | 9.2 | 9.6 | |
Lab II (exp.1) | 23.8 | 17.4 | |
23.1 | 15.5 | ||
mean | 23.5 | 16.4 | |
Lab II (exp.2) | 15.1 | ||
14.0 | |||
mean | 14.5 |
Description of key information
The lowest EC50 value was reported to be 9.6 mg/l. Acute toxicity of o-cresol to Daphnia pulex was determined in a static immobilization test after an exposure period of 48 h.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 9.6 mg/L
Additional information
Short term toxicity of o-cresol towards various species of aquatic invertebrates was assessed in several experiments.
For risk assessment purposes, only the most reliable and sensitivity study is considered.
The lowest toxicity value was obtained in an acute toxicity test of o-cresol to Daphnia pulex, determined in a static immobilization test after an exposure period of 48 h. The test was carried out in analogy to a Dutch standard method which is similar to OECD 202. In 3 laboratories, duplicate samples with each 25 individuals of <1 day old daphnids were exposed to the test solutions. Analytical confirmation of exposure levels was not performed. The lowest nominal EC50 was reported to be 9.6 mg/l.
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