Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Pattern of Response of Intact Drosophila to Known Teratogens
- Author:
- Schuler, R.L. et al.
- Year:
- 1 985
- Bibliographic source:
- J. Am. Coll. Toxicol. 4, 291-303
Materials and methods
- Principles of method if other than guideline:
- Method: other: teratogenic investigations
- GLP compliance:
- not specified
- Application method:
- oral
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from Aldrich Chemical Company;
Purity: "purest availabel grade from the vendor"
Constituent 1
Test organisms
- Test organisms (species):
- Drosophila melanogaster
Study design
- Study type:
- laboratory study
Results and discussion
Any other information on results incl. tables
A total number of 1262 flies were tested on the test substance 2 -ethoxyethanol.
Abnormalities observed:
- wing notches (9 µL P< 0.001)
- significant reduction of large bristles (macrosetae) (13 µL P < 0.01; 17 µL P < 0.001)
- size reduction of supra-alar bristles
- bent (humeral) bristles (13 µL P < 0.05; 17 µL P < 0.01)
Applicant's summary and conclusion
- Conclusions:
- The test substance 2-ethoxyethanol induced different developmental abnormalities like wing notches, size reduction of bristles and bending of bristles in Drosophila (adults and larvae).
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