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Diss Factsheets
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EC number: 248-145-0 | CAS number: 26966-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (additionally labeling of the tables unclear)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics
- Author:
- Marzulli FN, Anjo DM & Maibach HI
- Year:
- 1 981
- Bibliographic source:
- Food Cosmet.Toxicol. 19: 743-7
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Remarks:
- ; GLP was no compulsory at the time the study was conducted
Test material
- Reference substance name:
- 4-methyl-m-phenylenediamine
- EC Number:
- 202-453-1
- EC Name:
- 4-methyl-m-phenylenediamine
- Cas Number:
- 95-80-7
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 4-methylbenzene-1,3-diamine
- Details on test material:
- - Name of test material (as cited in study report): 2,4-TDA dihydrochloride
- Specific activity (if radiolabelling): 2.78 mCi/mmol
- Locations of the label (if radiolabelling): uniformly ring labeled
- Supplier: New England Nuclear
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- monkey
- Strain:
- other: Rhesus
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- acetone
- Duration of exposure:
- 24 h
- Doses:
- 4 µg/cm2 (area exposed 3-15 cm2, therefore it can be concluded that 12 - 60 µg TS were applied)
- No. of animals per group:
- 3 - 6
- Control animals:
- no
- Details on study design:
- TEST SITE
- Preparation of test site: clipping (no data on the time period between clipping and exposure available)
- Area of exposure: abdomen
USE OF RESTRAINERS FOR PREVENTING INGESTION: yes
REMOVAL OF TEST SUBSTANCE
- Washing procedures and type of cleansing agent: washing with soap and water
- Time after start of exposure: 24 h
SAMPLE COLLECTION
- Collection of urine: over a 5 day period with the intervals: 0-4 h, 4-8 h, 8-12 h, 12-24 h, 24-48 h, 48-72 h, 72-96 h (no information whether the urine between 96-120 h was really sampled or analysed is available)
- no information on whether the urine was pooled is available
ANALYSIS
- Method type for identification: Liquid scintillation counting for determination of overall radioactivity in urine
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
Percutaneous absorption
- Remarks on result:
- other:
Any other information on results incl. tables
- The absorption rate of [14C]2,4 -TDA in monkey skin was 53.8 ± 15.4% of the dose during 24 h, as extrapolated by the amount of radiotracer (14C) found in the urine over a 5-day period.
- 43% of the dose absorbed is excreted in urine within 96 h. The peak urinary excretion was between 8-12 h after application of the dose.
Table 1: Percentage of the [14C]2,4-TDA dose excreted by urine during the indicated interval
Monkey [% of the absorbed dose] | |
0-4 h | 1.0 |
4-8 h | 7.6 |
8-12 h | 12.7 |
12- 24 h | 9.3 |
24 - 48 h | 7.4 |
48 -72 h | 3.7 |
72 -96 h | 1.8 |
Total | 43.5 |
- excretion table was wrongly labeled.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.