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EC number: 265-062-5 | CAS number: 64741-60-2 A complex combination of hydrocarbons produced by the distillation of products from a catalytic cracking process. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C30 and boiling in the range of approximately 205°C to 450°C (401°F to 842°F). It contains a relatively large proportion of tricyclic aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is a well-documented study report that follows basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- yes
- Remarks:
- exposed prior to mating and through to day 20
- Principles of method if other than guideline:
- Female rats were administered test compound beginning 7 days prior to mating and continued through mating, and to gestation day 20. Dams were examined for general health and toxicity. Pups were examined for gross abnormalities at birth and body weights recorded on day 0 and 4. Pups were also sexed and observed for survival through day 4.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Light coker gas oil
- IUPAC Name:
- Light coker gas oil
- Reference substance name:
- 64741-82-8
- Cas Number:
- 64741-82-8
- IUPAC Name:
- 64741-82-8
- Test material form:
- other: low viscosity hydrocarbon liquid
- Details on test material:
- - Name of test material (as cited in study report): F-277, light coker gas oil
- Substance type: Cracked gas oil
- Light brown to orange-coloured viscous liquid with a slightly cracked or burnt to asphaltic odour
- Flash Pt (approx °F): >150
- Specific gravity (approx): 0.89-0.95
- Purity petroleum distillates
- Stability: stable
- Volatility: slight
- Storage conditions (°F): 80 or below
- Boiling Pt range (°F): 320-1100
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- unchanged (no vehicle)
- Details on mating procedure:
- presumed-pregnant females
- Duration of treatment / exposure:
- 6 hours
- Frequency of treatment:
- once daily
- Duration of test:
- Treated for one week prior to mating through day 20 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 50, 250 mg/kg
Basis:
- No. of animals per sex per dose:
- 12 females per treatment dose, 15 female sham controls
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
Dermal irritation at doses of 1, 50, and 250 mg/kg; increased absolute and relative food consumption at 50 mg/kg; decreased body weight, absolute food consumption during premating, increased relative food consumption during gestation, and increased absolute amd relative food consumption during lactation at 250 mg/kg.
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 1 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOEL
- Effect level:
- 50 mg/kg bw/day
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
Decreased pup body weight on lactation days 0 and 4 in the 250 mg/kg dose group.
Effect levels (fetuses)
- Remarks on result:
- other: see Details on embyotoxic/teratogenic effects
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The NOEL for maternal toxicity is 1 mg/kg/day. The NOEL for developmental toxicity is 50 mg/kg/day.
- Executive summary:
In a developmental toxicity study, presumed-pregnant Sprague-Dawley females (12/dose, 15 in sham control group) were dermally exposed to light coker gas oil for six hour of exposure at dose levels of 1, 50, or 250 mg/kg/day once daily at seven days before gestation through day 20 of gestation.
Maternal toxicity included dermal irritation at doses of 1, 50, and 250 mg/kg; increased absolute and relative food consumption at 50 mg/kg; decreased body weight, absolute food consumption during premating, increased relative food consumption during gestation, and increased absolute amd relative food consumption during lactation at 250 mg/kg. Decreased pup body weight on lactation days 0 and 4 in the 250 mg/kg dose group. Under conditions of the study, the NOEL for maternal toxicity is 1 mg/kg/day and for developmental toxicity the NOEL is 50 mg/kg/day.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is a well-documented study report that follows basic scientific principles.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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