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Diss Factsheets
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EC number: 305-998-4 | CAS number: 95465-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Not stated in the report: - acclimasation period and weight of animals were not stated - volume given to animals was not stated - Weight of animals was not stated - No information of environmental, housing and feeding conditions - No statement about fasting period, mortality, clinical observations, weighing, pathology, strain or source of animals
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted: 24 Feb. 1987
- Deviations:
- yes
- Remarks:
- some details are not stated in the report
- Principles of method if other than guideline:
- Not stated in the report:
- acclimasation period and weight of animals were not stated
- volume given to animals was not stated
- Weight of animals was not stated
- No information of environmental, housing and feeding conditions
- No statement about fasting period, mortality, clinical observations, weighing, pathology, strain or source of animals - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Barium chloride
- EC Number:
- 233-788-1
- EC Name:
- Barium chloride
- Cas Number:
- 10361-37-2
- IUPAC Name:
- barium dichloride
- Details on test material:
- - Name of test material (as cited in study report): BaCl2 (obtained from Fisher Scientific Company)
- Analytical purity: at least 98 % pure
No further significant information on test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Age at study initiation: adult: 60 -70 days of age; weanling: 21 - 25 days of age
No further significant information was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- BaCl2 was dissolved in distilled water and administered as a single dose by gavage.
- Doses:
- At least eight dose levels for adults
At least eight dose levels for weanlings - No. of animals per sex per dose:
- 10 animals per level
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
No further significant information on study design was stated. - Statistics:
- Statistical analyses were done separately for each sex at a significance of p<0.05.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- 95% CL:
- 424 - 600
- Remarks on result:
- other: LD50 for the weanling animals
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 300 mg/kg bw
- 95% CL:
- 255 - 369
- Remarks on result:
- other: LD 50 value for adult animals
- Mortality:
- not stated
- Clinical signs:
- other: not stated
- Gross pathology:
- not stated
- Other findings:
- not stated
Any other information on results incl. tables
The acute oral toxicity study was performed initally as a dose range finder to a 4, 8 and 13 week study (see Section 7.5.1 Repeated dose toxicity oral: s_Tardiff_1980).
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results indicated that LD50 of BaCl2 for the weanling animals was 500 mg /kg bw.; confidence limits, 424 - 600 with a slope of 6.2; whereas, the LD 50 of BaCl2 for the adult animals was 300 mg/kg bw.; confidence, 255 - 369 with a slope of 7.2. However, due to the fact that test animals which are between 8-12 of age should be used for testing, the relevant LD50 is 300 mg/kg bw. Accroding to GHS the substance has to be classified as toxic category III.
The results of the study indicates that BaCl2 was toxic cat 4 to adults and to weanlings. - Executive summary:
The results indicated that LD50 of Ba2+ for the weanling animals was 220 mg/kg bw. and the LD 50 of Ba2+ for the adult animals was 132 mg/k bw.
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