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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 201-286-1 | CAS number: 80-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- In accordance with column 2 of REACH Annex IX, section 9.2., further biotic degradation testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the degradation of the substance and its degradation products. The CSA does not indicate the need for further testing since RCRs are well below 1 for all environmental compartments, thus demonstrating safe use (highest RCR (OBSH) = 0.025 for agricultural soil, highest RCR (hydrazine) = 0.036 for fresh water). According to the ITS described in ECHA Guidance on Information Requirements and CSA, R.7b (Figure R.7.9-3), sufficient data is available fulfilling the three regulatory needs, i.e. environmental hazard classification, PBT/vPvB assessment and exposure assessment. Furthermore, according to the ECHA Guidance R.7b, simulation studies may be required for a substance to refine the persistence assessment for a substance. Even though OBSH and its two transformation products hydrazine hydrate and 4,4’-oxybis(benzenesulfonic acid) are not considered readily biodegradable, a PBT/vPvB concern can be ruled out since neither of the substances are bioaccumulative (please refer to the cross-references).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Assessed substance:
- transformation product
- PBT status of the assessed substance:
- the substance is not PBT / vPvB
- Remark:
- Hydrazine is inorganic and therefore the concept of biodegradability does not apply.
Hydrazine will degrade in aqueous media in the presence of metal ions and organic matter. The time for complete degradation will depend on the presence of both factors. Base on available experimental studies, the environmental half life of hydrazine in the aquatic compartment will be < 40 days and thereby the P criterion. is not fulfilled. - Conclusion on P / vP properties:
- not P/vP
- Remark:
- There is no experimental BCF available. The estimated BCF is 3.16 (log BCF 0.5, BCFBAF v3.02). Furthermore, rapid degradation and a low log Kow combined with high water solubility lead to the conclusion that the potential to bioaccumulate is low.
- Conclusion on B / vB properties:
- not B/vB
- other evidence
- Remark:
- Hydrazine is classified as Carc. Cat. 2.
- Conclusion on T properties:
- T
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Assessed substance:
- transformation product
- PBT status of the assessed substance:
- the substance is not PBT / vPvB
- Remark:
- There are no experimental data available. Based on in silico data generated by EPI Suite's BIOWIN models, 4,4’-oxybis(benzenesulfonic acid) does not biodegrade fast. The model Biodegradation ultimate (Biowin 3) indicates weeks-months for ultimate biodegradation.
The PBT Prioritizing Scheme integrated in the QECD QSAR Toolbox 4.4.1 indicates: P, not B.
--------------------------- BIOWIN v4.10 Results ----------------------------
SMILES : OS(=O)(=O)c1ccc(Oc2ccc(cc2)S(O)(=O)=O)cc1
CHEM :
MOL FOR: C12 H10 O7 S2
MOL WT : 330.33
--------------------------- BIOWIN v4.10 Results ----------------------------
Biowin1 (Linear Model Prediction) : Does Not Biodegrade Fast
Biowin2 (Non-Linear Model Prediction): Does Not Biodegrade Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks-Months
Biowin4 (Primary Biodegradation Timeframe): Days-Weeks
Biowin5 (MITI Linear Model Prediction) : Not Readily Degradable
Biowin6 (MITI Non-Linear Model Prediction): Not Readily Degradable
Biowin7 (Anaerobic Model Prediction): Does Not Biodegrade Fast
Ready Biodegradability Prediction: NO - Conclusion on P / vP properties:
- No conclusion can be reached based on available information
- Remark:
- There are no experimental data available. Based on in silico data generated by EPI Suite's BIOWIN models, 4,4’-oxybis(benzenesulfonic acid) does not biodegrade fast. The model Biodegradation ultimate (Biowin 3) indicates weeks-months for ultimate biodegradation.
The PBT Prioritizing Scheme integrated in the QECD QSAR Toolbox 4.4.1 indicates: P, not B. - Not B and not vB based on: Log Kow ≤ 4.5
- Remark:
- There is no experimental data available. Based on in silico calculations, the estimated log Kow is -0.06.
KOWWIN Program (v1.68) Results:
Log Kow(version 1.69 estimate): -0.06 - Not B and not vB based on: BCF ≤ 2,000 L/kg
- Remark:
- There are no experimental data available. Based on in silico calculations, the estimated BCF is 3.16 L/kg wet-wt.
BCFBAF v3.01:
Summary Results:
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.0715 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.02 (BAF = 0.962 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: -0.06
Equation Used to Make BCF estimate:
Log BCF = 0.50 (Ionic; Log Kow dependent)
Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt) - Conclusion on B / vB properties:
- not B/vB
- Remark:
- Based on the available data, the 4,4’-oxybis(benzenesulfonic acid) is not bioaccumulative. The PBT Prioritizing Scheme integrated in the QECD QSAR Toolbox 4.4.1 indicates: P, not B.
- Conclusion on T properties:
- No conclusion can be reached based on available information
- Remark:
- There are no data available. The automated workflow provided in the OECD QSAR Toolbox v. 4.4.1 cannot predict the LC50 for fish. In conclusion, no information on toxicity for 4,4’-oxybis(benzenesulfonic acid) is available.
Data source
Materials and methods
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Hydrazine, hydrate
- CAS number:
- 10217-52-4
- Identity:
- Hydrazine, monohydrate
- Identifier:
- EC number
- Identity:
- 10217-52-4
- Molecular formula:
- H6N2O
- Molecular weight:
- 50
- SMILES notation:
- NN.O
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 4,4’-oxybis(benzenesulfonic acid)
- CAS number:
- NA
- Molecular formula:
- C12H10O7S2
- Molecular weight:
- 330
- SMILES notation:
- OS(=O)(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)O)cc1
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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