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Diss Factsheets
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EC number: 223-861-6 | CAS number: 4098-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-08-12 to 1999-09-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- (1992)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- INOCULUM/TEST ORGANISM
- Species/strain: mixed population of aquatic microorganisms (activated sludge)
- Sampling site: aeration tank of a WWTP of Wupper area water authority, sampled 09 Aug 1999
- Pretreatment: none - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST SYSTEM
- Number of culture flasks per concentration: 3 each for test substance, blank control and reference substance; 2 for toxicity control
METHOD OF PREPARATION OF TEST SOLUTION
- Direct weighing
ANALYTICAL PARAMETER
- Dissolved oxygen
SAMPLING
- days 4, 6, 8, 12, 14, 18, 20, 22, 26, 28
TEST CONDITIONS
- Test temperature: 20 +/- 1 degree C
- Concentration of suspended solids: 30 mg/l
CONTROLS
- blank control, toxicity control, reference substance - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Kinetic of test substance (in %):
= 0 after 4 day(s)
= 0 after 14 day(s)
Kinetic of control substance (in %):
= 69 after 4 day(s)
= 88 after 14 day(s) - Results with reference substance:
- For sodium benzoate, 88 % degradation were observed within 14 days.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 0% biodegradation was observed during the test.
- Executive summary:
No biodegradation (0% degradation within 28 days) was observed in a manometric respiratory test performed with domestic, non-adapted activated sludge according to Directive 92/69/EEC, C.4-D (Bayer AG, 2000). The study was assessed as "reliable without restrictions".
Reference
The used concentrations of the test substance did not show toxic effects to bacteria. In a toxicity control a mean degradation of 55 % was achieved after 28 days. However, degradation of the reference substance was delayed.
Description of key information
No ready biodegradation (0% degradation within 28 days) was observed in a manometric respiratory test performed with domestic, non-adapted activated sludge according to Directive 92/69/EEC, C.4-D (Bayer AG, 2000).
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
A manometric respiratory test performed with domestic, non-adapted activated sludge according to Directive 92/69/EEC, C.4-D (Bayer AG, 2000) revealed 0% degradation of isophorone diisocyanate within 28 days. The substance is therefore regarded not readily biodegradable.
Biodegradation is of minor relevance because the reaction with water is expected to eliminate the substance rapidly, forming amines, CO2 and further polyurea.
The hydrolysis product isophorone diamine is not readily biodegradable either in a DOC-DIE Away test (EU method C.4 A) and polyurea is considered to be an inert material unable to be biodegraded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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