Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: In accordance with recognised guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- Lepomis macrochirus
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 17 d
- Total depuration duration:
- 10 d
- Nominal and measured concentrations:
- Average measured exposure concentration of 93 µ/L
- Details on estimation of bioconcentration:
- Calculated, based on measured residues
- Type:
- BCF
- Value:
- 122
- Basis:
- edible fraction
- Time of plateau:
- 1 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:19 µg/L
- Type:
- BCF
- Value:
- 877
- Basis:
- non-edible fraction
- Time of plateau:
- 1 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:19 µg/L
- Type:
- BCF
- Value:
- 621
- Basis:
- whole body w.w.
- Time of plateau:
- 1 d
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:19 µg/L
- Elimination:
- yes
- Parameter:
- DT50
- Depuration time (DT):
- 0.3 d
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a flow-through test with L. macrochirus, exposed to an average of 19 µg/L, based on the total radioactivity in fish, the BCF values are calculated to be 122, 877, and 621 in edible tissues, non-edible tissues, and whole fish respectively. After transferring the fish to clean flowing water, the radioactivity decreased very rapidly with half-lives ranging from 0.3 to 0.6 days. After 10 days depuration, residual radioactivity was below the limit of quantification.
- Executive summary:
In a flow-through test with L. macrochirus, exposed to an average of 19 µg/L, based on the total radioactivity in fish, the BCF values are calculated to be 122, 877, and 621 in edible tissues, non-edible tissues, and whole fish respectively. After transferring the fish to clean flowing water, the radioactivity decreased very rapidly with half-lives ranging from 0.3 to 0.6 days. After 10 days depuration, residual radioactivity was below the limit of quantification.
Reference
The residual radioactivity in fish body increased rapidly and reached a maximum after about one day of exposure. Thereafter, the concentration remained constant at 16 to 57, 11 to 65, and 0.9 to 13 µg parent equivalents/g fish in non-edible tissues, whole fish, and edible tissues, respectively. The residues in the edible and non-edible tissues were mainly comprised of CGA 153433. Because bioconcentration of the metabolite CGA 153433 was unlikely to occur (log POW = -0.75), it is assumed that cloquintocet-mexyl was accumulated and immediately metabolised into CGA 153433. Consequently, for the estimation of bioconcentration factors (BCF), it is assumed, that residual radioactivity in fish parts initially represented accumulated cloquintocet-mexyl. Based on the total radioactivity in fish, the BCF values are calculated to be 122, 877, and 621 in edible tissues, non-edible tissues, and whole fish respectively. After transferring the fish to clean flowing water, the radioactivity decreased very rapidly with half-lives ranging from 0.3 to 0.6 days. After 10 days depuration, residual radioactivity was below the limit of quantification.
Therefore, bioconcentration of cloquintocet-mexyl is not considered to be of concern as it is rapidly metabolised and eliminated in fish and since the primary metabolite of cloquintocet-mexyl (CGA 153433) has negligible bioaccumulation potential.
Description of key information
The bioaccumulation and depuration of cloquintocet-mexyl in bluegill sunfish (Lepomis macrochirus) was investigated in one study (Burri, 1993). The substance is rapidly metabolised and eliminated in fish, whilst the primary metabolite has negligible bioaccumulation potential.
Key value for chemical safety assessment
- BCF (aquatic species):
- 621 dimensionless
Additional information
The bioaccumulation and depuration of cloquintocet-mexyl (log Pow = 5.2)
in bluegill sunfish (Lepomis macrochirus) was investigated by Burri
(1993) using a dynamic flow-through system. The study was GLP compliant,
conducted to OECD TG 305 and is considered to be reliable without
restrictions.
The fish were continuously exposed (flow-through system) to 14C-labelled
cloquintocet-mexyl for 17 days. In the exposure water,
cloquintocet-mexyl was partially hydrolysed to Acetic acid,
2-[(5-chloro-8-quinolinyl)oxy]-, the main environmental metabolite of
cloquintocet-mexyl. The residual radioactivity in fish body increased
rapidly and reached a maximum after about one day of exposure. The
residues in the edible and non-edible tissues were mainly identified as
the metabolite. It is assumed that residual radioactivity in fish parts
initially represented accumulated cloquintocet-mexyl, which was then
immediately metabolised. Therefore, bioconcentration of
cloquintocet-mexyl is not considered to be of concern as it is rapidly
metabolised and eliminated in fish, whilst the primary metabolite of
cloquintocet-mexyl, ( Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-), has
negligible bioaccumulation potential.
Based on the total radioactivity in fish, the BCF values are calculated to be 122, 877, and 621 in edible tissues, non-edible tissues, and whole fish, respectively. After transferring the fish to clean flowing water, the radioactivity decreased very rapidly with half-lives ranging from 0.3 to 0.6 days. After 10 days depuration, residual radioactivity was below the limit of quantification.
Therefore, bioconcentration of cloquintocet-mexyl is not considered to be of concern as it is rapidly metabolised and eliminated in fish and since the primary metabolite of cloquintocet-mexyl, ( Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, has negligible bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.