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EC number: 231-823-5 | CAS number: 7757-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 30 September 2009 and 17 November 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. This study is conducted according to an appropriate guideline and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 15 September 2009 Date of Signature: 26 November 2009
- Type of method:
- flask method
- Remarks:
- The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
- Water solubility:
- 0.578 g/L
- Temp.:
- 20 °C
- pH:
- >= 7.4 - <= 7.6
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The water solubility of the test material has been determined to be 0.578 g/l of solution at 20.0 ± 0.5°C in un-buffered glass double-distilled water, resulting in sample solution pH’s in the range 7.4 to 7.6.
Reference
SEE ATTACHMENT FOR EXAMPLES OF TYPICAL CHROMATOGRAPHY
Preliminary testing:
Un-buffered glass double-distilled water
The preliminary estimate of water solubility, as equivalent test material concentration, was 0.870 g/l, with a final sample solution pH of 7.7.
pH 4 buffer solution
The preliminary estimate of water solubility, as equivalent test material concentration, was 1.48 g/l, with a final sample solution pH of 6.6. Calculations were performed from the sample solutions diluted by a factor of 50 for analysis.
pH 9 buffer solution
The preliminary estimate of water solubility, as equivalent test material concentration, was 0.782 g/l, with a final sample solution pH of 7.9. Calculations were performed from the sample solutions diluted by a factor of 10 for analysis.
Definitive test:
The mean phosphate peak areas relating to the standard and sample solutions are shown in the following tables:
Un-buffered glass double-distilled water
Solution |
Area |
Standard 42.0 mg/l |
3.195 |
Standard 43.8 mg/l |
3.328 |
Matrix blank |
none detected |
Sample 1A |
1.926 |
Sample 1B |
1.934 |
Sample 2A |
1.977 |
Sample 2B |
1.983 |
Un-buffered glass double-distilled water (continued)
Solution |
Area |
Standard 42.0 mg/l |
3.272 |
Standard 43.8 mg/l |
3.388 |
Sample 3A |
2.034 |
Sample 3B |
2.037 |
Sample 4A |
1.953 |
Sample 4B |
1.968 |
Sample 5A |
2.042 |
Sample 5B |
2.039 |
pH 4 buffer solution
Solution |
Area |
Standard 84.0 mg/l |
6.673 |
Standard 87.6 mg/l |
6.952 |
Matrix blank |
none detected |
Sample 1A |
3.926 |
Sample 1B |
3.951 |
pH 9 buffer solution
Solution |
Area |
Standard 42.0 mg/l |
3.298 |
Standard 43.8 mg/l |
3.413 |
Matrix blank |
none detected |
Sample 1A |
2.858 |
Sample 1B |
2.862 |
The equivalent concentration (g/l) of test material in the sample solutions is shown in the following tables:
Un-buffered glass double-distilled water
Sample |
Time Shaken at ~ 30ºC (hours) |
Equilibration Temperature (°C) |
Equilibration Time (hours) |
Equivalent Test Material Concentration |
Solution pH |
1 |
24 |
20 |
24 |
0.567 |
7.6 |
2 |
48 |
20 |
24 |
0.582 |
7.5 |
3 |
72 |
20 |
24 |
0.586 |
7.5 |
4 |
72 |
30 |
24 |
0.564 |
7.4 |
5 |
72 |
10 |
24 |
0.587 |
7.5 |
Mean concentration: 0.578
g/l at 20.0 ± 0.5ºC (samples 1 to 3 inclusive only)
Range: 0.567 to 0.586 g/l
(samples 1 to 3 inclusive only)
pH 4 buffer solution
Sample |
Time Shaken at ~ 30ºC (hours) |
Equilibration Temperature (°C) |
Equilibration Time (hours) |
Equivalent Test Material Concentration |
Solution pH |
1 |
72 |
20 |
24 |
1.11 |
6.8 |
pH 9 buffer solution
Sample |
Time Shaken at ~ 30ºC (hours) |
Equilibration Temperature (°C) |
Equilibration Time (hours) |
Equivalent Test Material Concentration |
Solution pH |
1 |
72 |
20 |
24 |
0.817 |
7.1 |
Description of key information
Water solubility: 0.578 g/L (EU Method A.6; GLP).
Key value for chemical safety assessment
- Water solubility:
- 0.578 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubilty of magnesium hydrogenorthophosphate has been determined to be 0.578 g/L, using the flask method, Method A.6 Water solubility.
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