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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 231-665-7 | CAS number: 7681-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Sodium hydrogensulfate dissociates in water to yield sodiums cations, as well as hydrogensulfate and sulfate ions in a pH-dependent equilibrium. For this reason, it is considered fully justified to also read across from existun data for sodium sulfate:
For sodium sulfate, an Ames test, a mouse lymphoma study and a chromosome aberration test is available. The Ames test did not show mutagenic effects (Bayer 1988). The in vitro mammalian cell gene mutation test (Wolny 2010) showed no substantial or reproducible dose dependent increase of the mutation frequency, and concluded on a lack of mutagenicity.
The chromosome aberration test (Hal 2010) showed no cytotoxic effects, and in both experiments in the absence and presence of S9 mix, no biologically relevant increase in the number of cells carrying structural chromosome aberrations was observed.
Based on the above test results, it is concluded that sodium sulfate has no genotoxic toxic potential.
Short description of key information:
No data specifically for sodium hydrogensulfate on genotoxicity are available, thus read-across from data on sodium sulfate was performed. Based on the absence of any indication of genotoxic effects in guideline-conform studies on bacterial reverse mutation, in-vitro cell gene mutation and in-vitro chromosomal aberration, it is concluded that sodium sulfate also lacks any genotoxic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on read-across from data on sodium sulfate (i.e. negative results in AMES, in-vitro cell gene mutation and in-vitro chromosomal aberration tests), it is concluded that sodium hydrogensulfate also lacks any genotoxic potential, and the substance therefore does not require classification for genotoxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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