Registration Dossier
Registration Dossier
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EC number: 204-812-8 | CAS number: 126-92-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96h LC50 (Danio rerio) > 100 mg/L (nominal concentration, OECD 203)
Key value for chemical safety assessment
Additional information
Since only limited information on short-term toxicity of C8-isoAS Na (CAS 126-91-2) to fish is available (limit concentration not reached), a read-across to another structurally related category member was conducted. Read-across data from C8AS Na (CAS 142-31-4) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that all the C8 homologues exhibit similar toxicity.
The key study with C8AS Na (CAS 142-31-4) was performed according to OECD 203 guideline and is GLP compliant (Neven 1993). Zebrafish (Danio rerio) were exposed for 96 hours to five test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). Since no toxic effects were observed up to the highest test concentration, the 96-hour LC50 value was determined above 100 mg/L (nominal concentration).
Moreover, a supporting short-term toxicity study with fish is available for C8-isoAS Na (CAS 126-91-2) (Wetton 1996). The test was performed according to OECD 203 guideline and GLP principles. Rainbow trout (Oncorhynchus mykiss) was exposed to the test substance in the semi-static limit conditions for 96 hours. Mortality of fish caused by the test substance was determined after 24, 48, 72 and 96 hours of exposure to the concentration 100 mg/L of 40% pure test substance which was equal to 40 mg/L of active ingredient. No analytical measurements are available. The test substance did not increase mortality in exposed fish and mortality in control group was below 10%. The results showed that the LC50 value was above 40 mg/L.
Due to structural and property similarities with the tested category member, it can be concluded that the above results apply also to C8-isoAS Na (CAS 126-92-1). The 96-hour LC50 value for fish is considered to be above 100 mg/L.
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