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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Full study report available. Acceptably well documented. Not to GLP

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sample no: 47-116. No further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Hilltop farms
- Weight at study initiation: 200-300g

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Vapour was produced by passing air at 2.5 l/min through the sample and then into a 9 litre animal chamber (dynamic conditions).
Analytical verification of test atmosphere concentrations:
no
Remarks:
nominal concentration only tested.
Duration of exposure:
6 h
Concentrations:
Animals exposed to a saturated atmosphere of test substance at 20C
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Temperature: 24C.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 1.2 mg/L air
Exp. duration:
6 h
Remarks on result:
other: Based on calculated maximum saturated vapour concentration.
Mortality:
None
Clinical signs:
other: None
Body weight:
With no control it is not possible to interpret the results. The females did appear to gain weight more slowly in first 7 days compared to days 7-14 and males.
Gross pathology:
None
Other findings:
No signs of toxicity were observed.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Substance has a very low acute toxicity when tested by the inhalation route up to the saturated vapour concentration
Executive summary:

In an acute toxicity study by the inhalation route, rats were exposed to the saturated vapour concentration of 2 -(2 -methoxyethoxy)ethanol for a period of 6 hours. This is estimated to be 1.2mg/l. No signs of toxicity were observed. Clearly, the substance has a low acute toxicity by the inhalation route.

Synopsis:

LC0 (6 hour, rat): >Saturated vapour pressure = 1.2mg/l