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EC number: 241-004-4 | CAS number: 16940-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: terrestrial
Administrative data
- Endpoint:
- bioaccumulation: terrestrial
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Boron and Selenium on Mallard Reproduction and Duckling Growth and Survival
- Author:
- Stanley , TR, GJ Smith, DJ Hoffman, GH Heinz and R Rosscoe.
- Year:
- 1 996
- Bibliographic source:
- Environmental Toxicology and Chemistry, Vol. 15, No 7. pp. 1124-1132, 1996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One hundred and twenty-six pairs of breeding mallards were fed diets supplemented with boron at 0, 450, or 900 ppm in combination with Se at 0, 3.5, or 7 ppm, in a replicated factorial experiment. Ducklings produced received the same treatment combination as their parents.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- IUPAC Name:
- 10043-35-3
- Reference substance name:
- boric acid
- IUPAC Name:
- boric acid
- Details on test material:
- - Name of test material (as cited in study report): boric acid
- Analytical purity: 99.9% pure ; Fisher Scientific, Fair Lawn, NJ, USA
Constituent 1
Constituent 2
- Radiolabelling:
- no
Sampling and analysis
- Details on sampling:
- - Sampling intervals/frequency for test organisms: the eighth egg was removed from each nest and 14d after hatching the ducklings and their parents were euthanized. Samples of liver, kidney, and spleen from 10 randomly selected hens, drakes, and ducklings were saved in 10% buffered formalin.
- Sample storage conditions before analysis: content of eggs were frozen, ducklings and parents were weighted and the liver removed, weighted and frozen for analysis
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods):
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: Anas platyrhynchos
- Details on test organisms:
- TEST ORGANISM
- Common name: mallards
- Source: Outdoorsman Hunting Club, Webb, IA, USA
- Age at test initiation (mean and range, SD): 1-year-old
- Weight at test initiation (mean and range, SD):
ACCLIMATION
- Acclimation period: 17 days
- Feeding : untreated diet of commercially available developer mash
- Females were kept under controlled lighting (8h/d) to delay the onset of egg laying and to synchronize their cycles
Study design
- Total exposure / uptake duration:
- ca. 120 d
Test conditions
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1m² outdoor pens
- No. of organisms per container (treatment): 1
- No. of replicates per treatment group: 14
- No. of replicates percontrol / vehicle control: 14 - Nominal and measured concentrations:
- Added concentrations in diet are 450 and 900 ppm boron
Results and discussion
Bioconcentration factoropen allclose all
- Type:
- BCF
- Value:
- 0.03 dimensionless
- Basis:
- organ d.w.
- Remarks on result:
- other: adult liver
- Type:
- BCF
- Value:
- 0.05 dimensionless
- Basis:
- organ d.w.
- Remarks on result:
- other: whole eggs
- Details on results:
- - Observations on body length and weight: weight loss in females between treatment onset and pairing (3 weeks) in the 900-ppm treatment group
- Other biological observations: egg weight and egg fertility were lower in the 900-ppm treatment group - Reported statistics:
- Data were analyzed by logistic regression under a mixed effects model with parameters for main and interactive effects between Band Se, and a pen effect. Parameters were tested for significance with F tests; multiple comparisons were made using contrasts. All remaining response wariables were analyzed by analysis of variance under a model appropriate for the main effects and interactions being tested and an error term suitable for unbalanced data. Tests of hypotheses that included more than one bird per pen were made with F tests under a mixed effects model using an appropriate error term. All other F tests assumed a fixed effects model and used the residual mean square as the error term. Normality of residuals was evaluated using the Shapiro-Wilk statistic and normal probability plots. Studentized residuals were plotted to assess homoscedasticity. Data that did not meet normality or homosccedasticity assumptions necessary for ANOVA were transformed so as to meet the assumptions. Consequently, all percentage data were arcsine transformed and all residue data were log. transformed before analysis. Multiple comparisons were made using Tukey's multiple comparison procedure (MCP) at alpha = 0.05.
Any other information on results incl. tables
Boron accumulates rapidly in adult mallard liver and is estimated to take 2.8d to reach 95% of its asymptotic level. On a dry-weight basis, B in adult liver in the control, 450 -, and 900 -ppm B treatments groups was 2, 15, and 27 ppm, respectively.
Dry-weight concentrations of B in eggs were 0.6, 22, and 38 ppm in the B control, and 450- and 900 -ppm treatment groups, respectively.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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