N-[3-(dimethylamino)propyl]stearamide

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted 27 July 1995

Deviations:

no

GLP compliance:

not specified

Type of method:

flask method

Water solubility:

10 mg/L

Temp.:

20 °C

pH:

6.8

Flask No.	Equilibration time at 20°C [h]	pH of aqueous solution	Solubility [mg/L]
1	24	7.7	9
2	48	6.8	9
3	72	6.8	11
mean			10

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of Stearic acid 3-(dimethylaminopropyl)amide is 10 mg/L at 20°C (pH 6.8).

Executive summary:

The water solubility of Stearic acid 3-(dimethylaminopropyl)amide was determined according to OECD guideline 105, 27 July 1995, using the flask method. The water solubility of Stearic acid 3-(dimethylaminopropyl)amide is 10 mg/L at 20°C (pH 6.8).

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2012-11-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: ISO 4311

Deviations:

no

Principles of method if other than guideline:

Determination of critical micelle concentration via surface tension

GLP compliance:

not specified

Type of method:

flask method

Water solubility:

220 mg/L

Temp.:

25 °C

Remarks on result:

other: critical micelle concentration

The surface tension vs. concentration plot showed a minimum at 0.22 g/L, which was taken as the best estimate of the critical micelle concentration (cmc).

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The critical micelle concentration of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride is 220 mg/L at 25°C.

Executive summary:

The critical micelle concentration (CMC) of Stearic acid 3-(dimethylaminopropyl)amide was determined according to ISO 4311, using the plate method. The CMC of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride is 220 mg/L at 25°C.

Description of key information

The water solubility of Stearic acid 3-(dimethylaminopropyl)amide is 10 mg/L at 20°C.

The critical micelle concentration (cmc) of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride is 220 mg/L at 25°C (ISO 4311, plate method).

Key value for chemical safety assessment

Water solubility:

10 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of Stearic acid 3-(dimethylaminopropyl)amide was determined according to OECD guideline 105, 27 July 1995, using the flask method. The water solubility of Stearic acid 3-(dimethylaminopropyl)amide is 10 mg/L at 20°C (pH 6.8).

However, based on the pKa the following distributions of free and protonated amine are present at different pH:

	free amine [%]	protonated amine [%]
pH 9	26.2	73.8
pH 7	0.4	99.6
pH 4	0	100

 

 

Surfactants show a complex solubility behaviour due to aggregation. The monomer concentration reaches a limiting value at the critical micelle concentration and remains approximately constant when the total concentration further increases.

The critical micelle concentration (cmc) of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride was determined according to ISO 4311, using the plate method. The cmc of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride is 220 mg/L at 25°C.