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Diss Factsheets
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EC number: 701-459-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Rating in accordance with OECD SIDS (2002)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- secondary source
- Title:
- SIDS - C.I. PIGMENT YELLOW 53
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Antimony nickel titanium rutile
- EC Number:
- 701-459-6
- Cas Number:
- 8007-18-9
- Molecular formula:
- Ni(x/3)Sb(2x/3)Ti(1-x)O2 0,1≤x≤0,3
- IUPAC Name:
- Antimony nickel titanium rutile
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: C.I. Pigment Yellow 53 was almost insoluble in water and showed a low toxicity by preliminary test. Consequently, the experiments were carried out with 1.00 mg/L at which precipitates and floating substances were not observed. However, it was likely that the test substance was not dissolved, because the presence of the test substance in the filtrate (the test solution was filtered with 0.45 µm membrane filter) was below the detection limit of ICP-MS operating condition.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Daphnia magna STRAUS
- Source: National Institute for Environmental Studies (JAPAN)
- Age of parental stock (mean and range, SD): < 24 h
- Feeding during test
- Food type: 0.2 mg carbon/day/individual (Chlorella vulgaris: Green Algae)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 240 - 265 mg/L
- Test temperature:
- 19.6 - 20.3 ºC
- pH:
- 7.3 - 8.4 (control)
- Dissolved oxygen:
- 7.5 - 8.7 mg/L
- Nominal and measured concentrations:
- Nominal Concentrations: control and 1.00 mg/L;
Stock Solution preparation and stability: 1000 mg/L stock solution was prepared for 1.00 mg/L tests, in the following way: 100 mg test substance was added in 100 mL dilution water. The test substance was not dissolved but dispersed in the stock solution. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 80 mL test solution in a 100 mL glass beaker with Teflon-lined sheet cap
- Renewal rate of test solution: every 24 h
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 (OECD Guideline 211)
- Photoperiod: 16:8 hours, light-darkness
- Light intensity: <800 lux - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- dispersed
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- dispersed
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- dispersed
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- dispersed
- Basis for effect:
- mortality
- Reported statistics and error estimates:
- - Statistical Method:
a) Data Analysis: LC50 of parental mortality: Binominal
NOEC and LOEC: t-test
b) Method of Calculating Mean Measured Concentrations (i.e.arithmetic mean, geometric mean, etc.): Not described
Any other information on results incl. tables
- Effect: Reproduction
- Measured concentrations (as mg/L):
----------------------------------------------------------------------------------------
Nominal Measured concentration (mg/L) on day:
----------------------------------------------------------------------------------------
Concentration 0 1 8 9 14 15
(mg/L) new old new old new old
----------------------------------------------------------------------------------------
Control <0.07 <0.07 <0.07 <0.07 <0.07 <0.07
1.00 0.88 0.83 0.90 0.15 0.94 0.88
----------------------------------------------------------------------------------------
- Effect data (reproduction):
21 days LC50 > 1.00 mg/L (95% C. I.: not available)
21 days EC50 > 1.00 mg/L (95% C. I.: not available)
21 days NOEC > 1.00 mg/L
21 days LOEC > 1.00 mg/L
- Cumulative number of died parental daphnids:
-----------------------------------------------------------------------------------------
Nominal Cumulative number of died parental daphnids
Concentration (days)
(mg/L) 1 2 3 4 5 6 7 8 9 10
----------------------------------------------------------------------------------------
Control 0 0 0 0 0 0 0 0 0 0
1.00 0 0 0 0 0 0 0 0 0 0
----------------------------------------------------------------------------------------
Nominal Cumulative number of died parental daphnids
Concentration (days)
(mg/L) 11 12 13 14 15 16 17 18 19 20 21
---------------------------------------------------------------------------------------
Control 0 0 0 0 0 0 0 0 0 0 0
1.00 0 1 1 1 1 1 1 1 1 1 1
--------------------------------------------------------------------------------------
- Time (days) of the first brood production: Mean;
Control: 8 days
1.00 mg/L: 8 days
- Mean cumulative number of offspring produced per adult: 21 days;
Control: 102.8
1.00 mg/L: 95.2
- Calculation of toxic values:
The calculation of the toxic values is based on the nominal concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Antimony nickel titanium rutile is not chronically toxic to Daphnia magna in a test according to OECD 211 with test suspensions prepared at nominal concentrations far exceeding its water solubility, and the respective NOEC for reproduction is estimated with > 1 mg/L (nominal, dispersed).
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