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EC number: 227-006-8 | CAS number: 5593-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- September 21, 1984 - October 19, 1984
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, method deviates from current guideline. Furthermore, the test material contained only 25 % titanium tetrabutanolate. The main component of the test material was kerosene (75 %).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Groups of 10 male rats were exposed to the test item aerosol for a single 4-hour period. Following exposure the rats were observed for a 14 day period or until death.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Titanium tetrabutanolate
- EC Number:
- 227-006-8
- EC Name:
- Titanium tetrabutanolate
- Cas Number:
- 5593-70-4
- Molecular formula:
- C16H36O4Ti
- IUPAC Name:
- titanium(4+) tetrakis(butan-1-olate)
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
- Details on test material:
- - Name of test material (as cited in study report): 1-Butanol, titanium(4+salt) salt; Tetrabutyl titanate, Haskell No. 15,538
- Substance type: organometal
- Physical state: liquid
- Analytical purity: 95-100 %
- Impurities (identity and concentrations): Possibly 0-5% 1-butanol
- Composition of test material, percentage of components: 25 % titanium tetrabutanolate - 75 % kerosene
- Lot/batch No.: TLF-6171, lot 1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River Breeding Laboratories Inc, Kingston, New York
- Age at study initiation: 8 weeks old
- Weight at study initiation: between 234-265 grams
- Housing: in pairs in 8" x 14" x 8" suspended, steel-mesh cages
- Diet (e.g. ad libitum): Purina Certified Rodent Chow #5002 ad libitum, except during exposure
- Water (e.g. ad libitum): ad libitum, except during exposure
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24-26°C
- Humidity (%): 36-67%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- Aerosol atmospheres of tetrabutyl titanate in kerosene were generated by pumping liquid test material into a Spraying System nebulizer. Air introduced at the nebulizer aerosolized the test material, and swept the aerosol stream into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- A gravimetric analysis was used to control the chamber atmosphere during exposure.
- Duration of exposure:
- 4 h
- Concentrations:
- Mean concentrations 3.7 mg/l, 11.0 mg/l and 13.0 mg/l
Figures represent concentrations of tetrabutyl titanate and kerosene, based on the colorimetric analysis - No. of animals per sex per dose:
- 10 males per dose
- Control animals:
- no
- Details on study design:
- Groups of 10 male rats were restrained in perforated, stainless steel cylinders with conical nose pieces. Each group was exposed for a single, 4-hour period to an aerosol atmosphere of tetrabutyl titanate in air. Following exposure the rats were returned to their cages, housed in pairs and provided food and water ad libitum. The rats were observed for clinical signs and weighed daily (excluding week-ends) throughout a 14-day recovery period or until death.
Two analytical methods were used in this study. A gravimetric analysis was used to control the chamber atmosphere during the exposure, and a colorimetric analysis was used to determine the total amount of test material in the atmosphere (tetrabutyl titanate and kerosene).
1. Gravimetric Analysis
To control the chamber concentration during exposure, measured volumes of chamber atmosphere were drawn through pre-weighed, glass-fiber filters at approximately 30 minute intervals. Filters were weighed on a Cahn 26 Automatic Electrobalance. Atmospheric concentration of particulate was calculated from the filter weight differential before and after sampling.
2. Colorimetric Analysis
To determine the total amount of test material (tetrabutyl titanate and kerosene) in the atmosphere, a colorimetric analysis for titanium metal was used. The filters from the gravimetric analysis were placed in a solution containing 5 mL of 10% sulfuric acid and 0.2 mL of 30% hydrogen peroxide. This solution reacts with the tetrabutyl titanate to give a yellow solution of free titanium metal. The solutions were centrifuged to remove filter particles, and diluted (if necessary) with H2SO4/H202 solution. Absorbance was read at 400 nm with a Bausch and Lomb Spectronic 2000. Standards were prepared by dissolving a known volume of test material (kerosene and tetrabutyl titanate) in H2SO4/H202 solution. Assuming a constant ratio of tetrabutyl titanate to kerosene in the atmosphere and in solution, the absorbance of chamber samples indicated the total amount of test material in the chamber.
Particle size (mass median diameter and percent respirable) were determined with a Sierra cascade impactor during each exposure. Chamber temperature was measured with a thermometer, chamber oxygen content was measured with a BioMarineB Model 225 oxygen analyzer, and relative humidity was measured with a BendixB Model 566 psychrometer.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: Approximate Lethal Concentration (ALC)
- Effect level:
- 11 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 3.7 mg/l - 0/10
11.0 mg/l - 1/10
13.0 mg/l - 0/10 - Clinical signs:
- other: During or immediately following exposure, some rats in all groups were lethargic, had no response when the chamber was tapped, wet perineum, diarrhea, decreased muscle tone, impaired breathing, and fur stained by the test material. Some rats exposed to 3.
- Body weight:
- Surviving rats in all groups had dose-dependent weight loss ranging from approximately 2-15% of initial body weight 1 day after exposure, followed by normal weight gain.
- Gross pathology:
- No gross pathology reported.
Any other information on results incl. tables
Atmospheric Characterization of Tetrabutyl Titanate
Concentration (mg/L) (a | ||||
Mean | S.D. | Range | Respirable (%) (b | Mass Median Diameter (um) |
3.7 | 1.4 | 0.98 -5.5 | 98 | 1.8 |
11.0 | 2.0 | 7.7 -14 | 97 | 2.3 |
13.0 | 2.2 | 8.8 -16 | 89 | 3.0 |
a) Represents concentration of tetrabutyl titanate and kerosene, based on the colorimetric analysis.
b) Percent by weight of particles with aerodynamic diameter less than 10um.
Atmospheres of concentration greater than 13mg/L could not be generated due to an inadequate analytical method.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The result of this study cannot be used to evaluate the acute inhalation toxicity of titanium tetrabutanolate, since the composition of the tested material was 25 % titanium tetrabutanolate and 75% kerosene. However, an approximate lethal concentration (ALC) of this test material was determined to be 11mg/L under conditions of this study.
- Executive summary:
Male rats were exposed to aerosol atmospheres of 25% titanium tetrabutanolate - 75 % kerosene. An LC50 could not be calculated from these data. However, ALC was determined to be 11mg/L. By the study report titanium tetrabutanolate is considered slightly toxic by inhalation.
This study was regarded not reliable since the composition of the tested material contained only 25 % titanium tetrabutanolate. Furthemore, the study report is missing details on test conditions and test results. Thus, the result is used as a weight of evidence in hazard assessment.
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