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EC number: 232-160-4 | CAS number: 7789-38-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: review
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review by a recognised source.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- Review of data. Some investigations were performed with potassium bromate. A read across to sodium bromate is justified as both substances dissociated in water.
Test material
- Reference substance name:
- Sodium bromate
- EC Number:
- 232-160-4
- EC Name:
- Sodium bromate
- Cas Number:
- 7789-38-0
- Molecular formula:
- BrHO3.Na
- IUPAC Name:
- sodium bromate
- Details on test material:
- Some investigations were performed with potassium bromate. A read across to sodium bromate is justified as both substances dissociated in water.
Constituent 1
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Bromate appears to be rapidly absorbed from the gastrointestinal tract, at least in part unchanged, following oral administration.
- Type:
- distribution
- Results:
- Studies in rats indicate that bromate appears in plasma and urine rapidly following ingestion. Oral gavage administration of 100 mg KBrO3/kg to rats resulted in a peak plasma concentration 15 minutes after dosing and a peak urine concentration 1 hour p.a
- Type:
- metabolism
- Results:
- Bromate is reduced to bromide in body tissues.
- Type:
- excretion
- Results:
- Bromate is excreted mainly in the urine, partly as bromate and partly as bromide. Some bromate may also be eliminated in the feces.
- Type:
- other: bioaccumulation
- Results:
- Small amounts of bromine (1–2 ppm) were detected in the adipose tissue of mice, but not of rats, fed bread treated with potassium bromate in a lifetime study.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Bromide.
Applicant's summary and conclusion
- Conclusions:
- Bromate is rapidly absorbed from the gastrointestinal tract, at least in part unchanged. It is distributed throughout the body appearing in plasma and urine unchanged and in other tissues as bromide. Bromate is reduced to bromide in several body tissues, probably by GSH or other sulfhydryl-containing compounds. Most bromate is excreted in the urine, either as bromate or bromide, but some may leave the body in the feces.
Bromine has been detected in adipose tissue of mice following long-term treatment with bromate. - Executive summary:
Bromate is rapidly absorbed from the gastrointestinal tract, at least in part unchanged. It is distributed throughout the body appearing in plasma and urine unchanged and in other tissues as bromide. Bromate is reduced to bromide in several body tissues, probably by GSH or other sulfhydryl-containing compounds. Most bromate is excreted in the urine, either as bromate or bromide, but some may leave the body in the feces. Bromine has been detected in adipose tissue of mice following long-term treatment with bromate.
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