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Diss Factsheets
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EC number: 241-677-4 | CAS number: 17689-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a seven-day range-finding study conducted to determine appropriate doses for administration in an OECD TG 422 study, a NOAEL could not be determined for triacetoxyethylsilane due to the corrosive effects of this substance on the oesophagus and stomach (DCC, 2004).The study was not conducted to a guideline or to GLP since it was a range-finder only.
On the basis of this result and results of the skin corrosion studies, it is concluded that it is not feasible to conduct the OECD TG 422 study, which is in agreement with the decision of the US EPA.
Key value for chemical safety assessment
Additional information
The only repeated dose toxicity data available are from a 7-day range-finding study (DCC, 2004). This 7-day range-finder study indicated that a maximum dose level of less than 20 mg/kg/day would be required for a longer duration repeated dose study in order to avoid death or obvious suffering due to the corrosivity of the hydrolysis product, acetic acid. The data provided in this range-finder study indicate a practical and humane dose range for subsequent longer term studies is below the limit of technical practicality and toxicological significance.
As a result of the corrosive findings in this study, the following was concluded regarding the full OECD TG 422 study (as reported in DCC, 2006):
"The results and concerns regarding animal welfare were discussed with the EPA and resulted in EPA's acceptance of the Sponsor's request for a reduced testing rationale for ethyltriacetoxysilane. The reduced testing rationale included not conducting the combined repeated dose toxicity with the reproductive/developmental toxicity screening test for ethyltriacetoxysilane in Sprague-Dawley rats. In addition, ethyltriacetoxysilane was reviewed at SIAM 21 where it was determined that this chemical possesses properties indicating a hazard for human health (severe irritation and corrosivity caused by acetic acid)."
In response to the EPA's acceptance of reduced testing rationale the full OECD TG 422 study was cancelled.
Justification for classification or non-classification
Triacetoxyethylsilane is not classified for specific target organ toxicity following repeated doses by any route according to Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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