Bis(pentabromophenyl) ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed prior to international guidelines and GLPs.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1974

Reference 2

Reference Type:

publication

Title:

Toxicology and human health assessment of decabromodiphenyl ether

Author:

Hardy et al.

Year:

2009

Bibliographic source:

Critical Reviews in Toxicology 39(S3):1-44

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test conducted prior to international guidelines. However, performance was consistent with today's guidelines.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis(pentabromophenyl) ether

EC Number:

214-604-9

EC Name:

Bis(pentabromophenyl) ether

Cas Number:

1163-19-5

Molecular formula:

C12Br10O

IUPAC Name:

bis(pentabromophenyl) ether

Test animals

Species:

rat

Strain:

other: Spartan

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

1 h

Concentrations:

see below

No. of animals per sex per dose:

see below

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 48.2 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Any other information on results incl. tables

see below

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Groups of 5 male and 5 female Spartan rats were exposed for 1 h to 2 or 48.2 mg/L of a commercial DecaBDE product (DE-83) particles in air and subsequently observed for 14 days. All rats survived. Dyspnea and ocular discharge were noted from 2 mg/L concentration (1 animal); moreover, in the 48.2 mg/L group, eye squint and increasing motor activity were observed. All rats were normal at the end of 14-day observation period. Necropsies were not performed.

Executive summary:

Groups of 5 male and 5 female Spartan rats were exposed for 1 h to 2 or 48.2 mg/L of a commercial DecaBDE product (DE-83) particles in air and subsequently observed for 14 days. All rats survived. Dyspnea and ocular discharge were noted from 2 mg/L concentration (1 animal); moreover, in the 48.2 mg/L group, eye squint and increasing motor activity were observed. All rats were normal at the end of 14-day observation period. Necropsies were not performed.