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Diss Factsheets
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EC number: 910-757-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of divinylbenzene and ethylstyrene
- EC Number:
- 910-757-7
- Cas Number:
- N/A
- Molecular formula:
- Divinylbenzene: C10H10 Ethylstyrene: C10H12
- IUPAC Name:
- Reaction mass of divinylbenzene and ethylstyrene
- Details on test material:
- Vapor phase chromatograph (VPC) analysis :
Divinylbenzene 55.7%, Ethylvinylbenzene 40.4%, Diethylbenzene 4.5%, Mass 144-146 1.7%, Naphthalene 0.4%, t-Butyl Catechol 1010 ppm, Polymer 4 ppm
The percentage was determined by measuring the percent area of each component shown in the vapor phase chromatograph and is
considered to be approximately equal to weight percent.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Twenty-four hours prior to applying the test compound, the entire trunk of twelve rabbits, six males and six females, was clipped free of hair with electric clippers. Doses of 2.0, 3.98 or 7.95 g/kg body weight of the liquid were applied to the skin of the rabbits under a heavy gauge plastic cuff. The cuff was held in place with rubber bands and a cloth bandage taped securely to the marginal hair. At the end of the 24-hour exposure period, the cuffs were removed and the skin was washed with soap and water, rinsed thoroughly and dried with a cloth towel.
- Duration of exposure:
- 24 hours
- Doses:
- 2.0, 3.98 or 7.95 g/kg body weight
- No. of animals per sex per dose:
- 2/sex/dose
- Control animals:
- no
- Details on study design:
- The animals were observed for signs of toxicity during the exposure and periodically for two weeks thereafter. Body weights were recorded before and after the 24-hour exposure and at intervals up to 2 weeks post-application or until any initial loss of body weight was regained.
- Statistics:
- LD50 was calculated in accordance to: Weil CS (1952) . Tables for convenient calculation of median-effective dose (LD50 or ED50) and instructions in their use, Biometries, 8: 249-263.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 other: g/kg
- 95% CL:
- 4.5 - 11.8
- Remarks on result:
- other: The LD50 was calculated to be 8.0 g/kg (95% Confidence Limits 4.5 to 11.8 g/kg) with the assumption that a dose of 15.8 g/kg would kill 100% of the animals.
- Mortality:
- Mortality was observed in two of the four animals at the 7.95 g/kg dosage level. Death of these animals occurred on the third day after dosing. All other animals survived.
- Clinical signs:
- other: other: other: other: None
- Gross pathology:
- None
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was calculated to be 8.0 g/kg (95% Confidence Limits 4.5 to 11.8 g/kg).
- Executive summary:
An acute dermal study was conducted using methods equivalent to OECD Guideline 402. Twenty-four hours prior to applying the test compound, the entire trunk of twelve rabbits, six males and six females, was clipped free of hair with electric clippers. Doses of 2.0, 3.98 or 7.95 g/kg body weight of the liquid were applied to the skin of the rabbits under a heavy gauge plastic cuff. The cuff was held in place with rubber bands and a cloth bandage taped securely to the marginal hair. At the end of the 24-hour exposure period, the cuffs were removed and the skin was washed with soap and water, rinsed thoroughly and dried with a cloth towel. The animals were observed for signs of toxicity during the exposure and periodically for two weeks thereafter. Body weights were recorded before and after the 24-hour exposure and at intervals up to 2 weeks post-application or until any initial loss of body weight was regained.
Mortality was observed in two of the four animals at the 7.95 g/kg dosage level. Death of these animals occurred on the third day after dosing. All other animals survived. Surviving animals lost weight after exposure and returned to starting weight levels slowly. No clinical signs were observed throughout the study. The LD50 was calculated to be 8.0 g/kg (95% Confidence Limits 4.5 to 11.8 g/kg).
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