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EC number: 230-743-8 | CAS number: 7299-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Conclusions for environmental fate and pathways of 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) are based on read across from analogue substances of an existing category (pentaerythritol esters), of which the members were notified under Directive 67/548/EEC (NONS) in 2003/2004. The term 'read-across' for the substances other than the substance of interest means that these endpoints were already read-across in the existing category. Only NONs dossier data are available, which does not present adequate robust study summaries. In addition, full study reports are not available for the majority of substances.
Information on the environmental fate and pathways of the members of the category, including EC# 230-743-8, is summarized in the table below.
Endpoint | Guideline | CAS 144971-11-9 | CAS 131459-39-7 | CAS 452-180-9 | CAS 7299-99-2 |
Physchem |
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Melting/freezing / Pour point | OECD 102 | < -80.5 | < -36 | -30 | 9 deg C |
Boiling point | OECD 103 | dec >175 deg C | 399 deg C | 386 deg C | 415 deg C |
Relative density | OECD 109 | 0.97 | 0.96 | 0.97 | 0.9634 |
Vapour pressure | OECD 104 | 5.7 E-03 | 1.9 | 0.38 | 0.000000306 Pa at 20 °C |
Water solubility | OECD 105 | <0.2 mgl | <0.1 mg/l | <0.2 mmg/l | < 0.4 µg/l. |
n-Octanol-water partition coefficient | OECD 117 / 107 | >6.7* | >7.0* | >6.7* | Read-across: > 6.7; Calculated at 12.34 |
Flash point or flammability | EU A9 / A10 | 215.5 deg c | 260 deg c | 274 deg c | 213 deg c |
Explosivity | EU 14 | waived | waived | waived | Not explosive |
Auto-flammability | EU A15 | 405 | 400 | 415 | waived as FP > 200 Deg C |
Viscosity | OECD 114 | Not listed | Not listed | Not listed | 44 at 40°C |
Mammalian Toxicity | |||||
Acute oral toxicity | OECD 423 | > 2000 | > 2000 | > 2000 | > 2000 mg/kg bw |
Ames test | OECD 471 | negative | No data | negative | Negative |
Since the members of the category have similar physico-chemical properties, their behaviour in the environment is also similar. None of the substances tested was readily biodegradable. Hydrolysis, if possible, would generate the starting materials again. Therefore, the category approach is justified.
The substance appears to fulfil the criteria of “H413 - May cause long lasting harmful effects to aquatic life” as the substance is not readily biodegradable by testing and the log Pow is considered to be above 3. A partition coefficient in excess of 3 is considered to be of concern as potential for bioaccumulation. The likely reliability of the log Pow is, however, considered to diminish above a value of 6. Substances with log Pow between 3 and 6 are considered highly accumulating; however no substantial bioconcentration is assumed for compounds having log Pow with values less than 3 or greater than 6. This correlation has been validated by comparison of published BCF values with the respective calculated log Pow values; the results generally revealing increasing BCF values with increasing log Pow. For compounds having log Pow greater than 6, a gradual decrease of the BCF is observed. It has been hypothesised within the published literature that a high log Pow is more an effect of solubility than a tendency of the substance to be lipophilic.
Suitable references for this are listed in:
Nagel, R. ; Loskill, R.: Bioaccumulation in Aquatic Systems - Contributions to the Assessment.Proceedingsof an International Workshop Weinheim: VCH Verlagsgesellschaft, Fraunhofer IUCT (now IME), 1991 ISBN: 3-527-28395-1 pp.43-66 : Abb.,Tab.
Gary M Rand: Fundamentals of Aquatic Toxicology, Effects, Environmental Fate and Risk Assessment
Second Edition; Taylor & Francis, 1995, ISBN:1-56032-091-5 pp.626-629
Guidance for Meeting the SIDS Requirements: Chemical Right-to-Know Initiative,
http://www.epa.gov/opptintr/chemrtk/sidsappb.htm, Section 2.5
The Revised GESAMP Hazard Evaluation Procedure for Chemical Substances Carried by Ships, IMO/FAO/UNESCO±IOC/WMO/WHO/IAEA/UN/UNEP, Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection (GESAMP),The Revised GESAMP hazard evaluation procedure; Pow ca. >7.0 equates to BCF not measurable
All members of the category have low water solubility and high Log Kow. Since the few substances tested by experiment were strongly retained on the stationary phase, the log Koc for most substances was determined by QSAR calculation. All members of the category have a Log Koc>= 4.3 (Koc > 19952)meaning that they absorb strongly to organic material. Hence mobility in soil will be low. However, as the substance is not manufactured in Europe and at formulation or use waste is not disposed of via a waste water treatment plant, but incinerated, the environment is not expected to be exposed.
Using EPISuite 4.0 the log Kocof 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2- ethylhexanoate) (EC# 230 -743 -8) was calculated as 9.2 (estimate from MCI (Molecular Connectivity Index)) and 7.6 (estimated from log Pow)
Log Koc can provide insight as to whether a material will cling to soils or sediments in water and whether they will desorb or be tightly bound. Based on information from NTIS ((Review of Exposure Assessment Guidelines, September 1996), approximate indications of relative soil absorption potential are as follows:
Low potential: Koc = 1 to 100, log Koc = 0 - 2
Moderate potential: Koc = 100 to 10,000, log Koc = 2 - 4
High potential: Koc = 10,000 to 10,000,000, log Koc 4 - 7
A high potential would indicate that a material would bind tightly to soils and sediments and thus, reduce overall exposure potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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