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Diss Factsheets
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EC number: 204-596-5 | CAS number: 123-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is well conducted and acceptable for endpoint evaluation. No guideline was followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - no guideline mentioned and limited reporting
- remark: study based on dermal toxicity and skin studies - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethylhexanal
- EC Number:
- 204-596-5
- EC Name:
- 2-ethylhexanal
- Cas Number:
- 123-05-7
- Molecular formula:
- C8H16O
- IUPAC Name:
- 2-ethylhexanal
- Details on test material:
- - Name of test material (as cited in study report): 2-ethylhexyl aldehyde
- Physical state: not reported
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no details reported
TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation (g): M 251-264, F 205-218
- Fasting period before study: not reported
- Diet (e.g. ad libitum): not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: not reported
- % coverage: not reported
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24h exposure residual test substance was washed off with running water
- Time after start of exposure:
TEST MATERIAL
- Amount applied (volume or weight with unit): limit dose 20 ml/kg bw (16440 mg/kg bw)
- Constant volume or concentration used: yes - Duration of exposure:
- not reported
- Doses:
- undiluted substance administered
- Volume: 20 ml/kg bw - calculated 16440 mg/kg bw (density at 20°C 822 mg/ml) - No. of animals per sex per dose:
- 5 animals per sex and dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: not reported
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 440 mg/kg bw
- Remarks on result:
- other: no mortalities at limit dose
- Mortality:
- no mortality observed
- Clinical signs:
- - erythema was observed in all animals at the application site after termination of exposure period
- by day4: all male animals are without substance related effects while females continue showing erythema until day8 - Body weight:
- normal body weight gain in all animals
- Gross pathology:
- not reported
- Other findings:
- - Other observations: no signs of percutaneous adsorption
Applicant's summary and conclusion
- Executive summary:
The study is reliable with acceptable restrictions mostly due to limited documentation (e.g. body weight only determined for dose calculation prior to application). A single limit dose of 20 ml/kg bw (calculated 16440 mg/kg bw) of the test substance was applied on rats for 24h. 5 animals per sex were used in the. No mortality and no substance related clinical findings were reported within, besides erythema occurrence at the application site after termination of exposure. Erythema formation was reversible within 14 days. No signs of percutaneous adsorption were observed.
2-ethylhexanal is practically nontoxic when in contact with skin.
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