Registration Dossier
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EC number: 407-430-1 | CAS number: 3741-80-8 CP22595; SANTOCURE TBS1
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A direct study on the rate of hydrolysis of TBSI is not relevant, nor possible because of the low water solubility of TBSI (1.75 µg/L). However a study on the stability for hydrolysis on a structural analog (TBBS) showed a half life for hydrolysis of approximately 8 hrs. For TBSI a similar half life would be expected, though somewhat slower due to steric hindrance and the very low water solubility.
Key value for chemical safety assessment
Additional information
A direct study on the rate of hydrolysis of TBSI is not relevant, nor possible because of the low water solubility of TBSI (1.75 ug/L). However a study on the stability for hydrolysis on a structural analog (TBBS) was carried out, which showed a half life for hydrolysis of approximately 8 hrs. Based on its similar chemical structure TBSI is also expected to be hydrolysed with the same mechanism, though somewhat slower than TBBS because of its very low water solubility and its additional mercaptobenzothiazole group.
Rationale for using TBBS data for TBSI:
TBSI contains two benzothiazolesulfenamide groups attached to t-butylamine. In TBBS one of the bezothiazolesulfenamide groups is replaced by a hydrogen atom. The hydrolytic attack on TBBS, cleaving the N-S bond, is completely similar for TBBS and TBSI. So the results obtained for TBBS can be directly translated to TBSI, taking into account the steric hindrance of the additional benzothiazolesulfenamide group and the lower water solubility of TBSI compared to TBBS.
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