Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-036-0 | CAS number: 603-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 18.03. - 02.04.1952
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: screening test: discrepancy between documented test parameters and standard methods; only 2 animals were used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 952
- Report date:
- 1952
Materials and methods
- Principles of method if other than guideline:
- - Procedure: A suspension of 10- or 20-% test substance in olive oil equivalent to a dose of 300 mg/kg was applied daily (5 injection per week, max. 1 injection per day) intramuscular to one rabbit. The animal was observed for clinical signs of intoxication and mortality. the deceased animal was inspected for macroscopic and microscopic pathological changes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Triphenylphosphine
- EC Number:
- 210-036-0
- EC Name:
- Triphenylphosphine
- Cas Number:
- 603-35-0
- Molecular formula:
- C18H15P
- IUPAC Name:
- triphenylphosphine
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- olive oil
- Duration of treatment / exposure:
- 13 days
- Frequency of treatment:
- 1x/d, max. 5x/wk
Doses / concentrations
- Dose / conc.:
- 300 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- Post-exposure period: 2 days
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Signs of intoxication were observed from day 10 after the start of the study.
The animal showed ataxia and paralysis of the hind limbs from day 10 on and apathy and atony of the whole body at day13.
Before death, lateral positioning and labored breathing was observed. - Mortality:
- mortality observed, treatment-related
- Description (incidence):
- A dose of 300 mg/kg was lethal after 15 days (9 injections).
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- Macroscopic pathology revealed no characteristic substance-related findings: cachexia, cardiac flaccidity, collapsed/condensed lungs in one case, no significant lesions of the CNS.
- Neuropathological findings:
- no effects observed
- Description (incidence and severity):
- Histopathology including CNS revealed no relevant effects.
Applicant's summary and conclusion
- Executive summary:
A suspension of 10- or 20-% test substance in olive oil equivalent to a dose of 300 mg/kg was applied daily (5 injection per week, max. 1 injection per day) intramuscular to one rabbit. The dosing was paused from day 14 on due to severe clinical symptoms.
A dose of 300 mg/kg was lethal after 15 days (9 injections).
The animal showed ataxia and paralysis of the hind limbs from day 10 on and apathy and atony of the whole body at day13.
Before death, lateral positioning and labored breathing was observed.
Macroscopic and microscopic pathology revealed no characteristic substance-related findings: cachexia, cardiac flaccidity, collapsed/condensed lungs in one case, no significant lesions of the CNS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.