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Diss Factsheets
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EC number: 207-980-0 | CAS number: 504-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January to February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- We believe the results are correct but due to their age detail is brief and there is no indication of GLP compliance. However the report was accepted by the quality assurance unit of the testing house as being an accurate presentation of the findings of the study at the time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A 10%w/v solution of the test substance was administered by oral intubation at arange of dosage volume of 4 -40ml/Kg body weight. control rats
were treated with distilled water alone at a dosage of 40ml/Kg bodyweight - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,3 Cyclohexanedione
- IUPAC Name:
- 1,3 Cyclohexanedione
- Details on test material:
- - 1,3 Cyclohexanedione
- Molecular formula (if other than submission substance):
- Molecular weight (if other than submission substance):
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state:
- Analytical purity:
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.:
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material:
- Other:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 91 to 129 gm
- Fasting period before study: Overnight
Administration / exposure
- Route of administration:
- other: oral intubation
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% w/v
- Amount of vehicle (if gavage): 4 to 40ml/Kg bodyweight
- Justification for choice of vehicle: Test substance solubility
- Lot/batch no. (if required):
- Purity:
MAXIMUM DOSE VOLUME APPLIED: 4gm/Kg bodyweight - Doses:
- 0.4gm to 4.0gmof test substance per Kg of bodyweight
- No. of animals per sex per dose:
- 2 males and 2 females per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: All animals surviving terminally were examined macroscopically to detect possible residual damage
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 1 600 - <= 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- See attached full study report
- Clinical signs:
- other: See attached full study report
- Gross pathology:
- See attached full study report
- Other findings:
- See attached full study report
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal oral dose (LD50) to rats of 1,3 - cyclohexanedione was found to be between 1.6 and 2.5g/Kg bodyweight
- Executive summary:
The acute oral toxicity of 1,3 - Cyclohexanedione to rats was determined by oral intubation of a range of dosages of a 10%w/v test solution. The dosage volume range was 4.0 to 40ml/Kg bodyweight. The observation period was 14 days during which time a record was kept of all mortalities and signs of mortality. The acute median lethal oral dose (LD50) to rats of 1,3 - cyclohexanedione was found to be between 1.6 and 2.5g/Kg bodyweight
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