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EC number: 209-711-2 | CAS number: 591-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-01-28 to 2005-05-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Principles of method if other than guideline:
- The water solubility of 3-aminophenol is determined.
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Name of test material: 3-aminophenol
- IUPAC name: 1-Hydroxy-3-amino-benzene
- Molecular weight: 109.127 g/mole
- Molecular formula: C6H7NO
- Smiles: c1c(cccc1O)N
- InChI: 1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- Substance type: Organic
- Physical state: Solid Crystalline (white)
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 220117
- Expiration date of the lot/batch: september 2005
- Purity test date: 2004-08-31
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at +4°C, protected from light and under nitrogen gas
- Stability under test conditions: nd
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no - Key result
- Water solubility:
- 20 100 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6.08 - <= 6.22
- Remarks on result:
- other: +/- 2.9 g/L
- Details on results:
- Preliminary test: This test was performed at room temperature and under nitrogen atmosphere in vessels protected from light. The preliminary test indicated that the test item was soluble in water with a solubility above 10 mg/L. Hence the final determination was undertaken using the flask method.
Flask method: the test was performed at 20°C+/- 0.5°C, in vessels protected from light. The water solubility was found to be 20.1+/-2.9 g/L with a precision of 14%. In the 3 replicate solutions prepared, the pH values were found to be acid (6.08 for replicate 1, 6.11 for replicate 2 and 6.22 for replicate 3). - Conclusions:
- The solubility of the test item 3-aminophenol in water was found to be 20100.0 mg/L (20.1 g/L) at 20°C. The resulting saturated solution were acid and colorless.
- Executive summary:
The solubility in water of the test item was determined according to the OECD 105 guideline and GLP. The water solubility was first evaluated in a preliminary test indicating a solubility value above 10 mg/L. Hence the final determination was undertaken using the flask method and HPLC/UV as analytical method. The water solubility of the test item was found to be 20100.0 mg/L (20.1 g/L) at 20°C using the flask method. The resulting saturated solutions were acid and colorless.
Reference
Description of key information
The solubility of the test item 3-aminophenol in water was found to be 20100.0 mg/L (20.1 g/L) at 20°C. The resulting saturated solution were acid and colorless.
Key value for chemical safety assessment
- Water solubility:
- 20 100 mg/L
- at the temperature of:
- 20 °C
Additional information
The solubility in water of the test item was determined according to the OECD 105 guideline and GLP. The water solubility was first evaluated in a preliminary test indicating a solubility value above 10 mg/L. Hence the final determination was undertaken using the flask method and HPLC/UV as analytical method. The water solubility of the test item was found to be 20100.0 mg/L (20.1 g/L) at 20°C using the flask method. The resulting saturated solutions were acid and colorless.
Other supporting data from another experimental study, reliable handbooks, various authoritative databases and publications, also determined the water solubility of 3-aminophenol as 29900 mg/L at 35°C, 26000 mg/L at 20°C, 25000 mg/L at 20°C, 27000 mg/L at 20°C, 26300 mg/L at 20°C respectively.
Hence on the basis of obtained values the 3-aminophenol is considered to be very soluble in water.
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